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Erratum: BRaf signaling principles unveiled by large-scale human mutation analysis with a rapid lentivirus-based gene replacement method

Authors :
Chae-Seok Lim
Xi Kang
Vincent Mirabella
Huaye Zhang
Qian Bu
Yoichi Araki
Elizabeth T. Hoang
Shiqiang Wang
Ying Shen
Sukwoo Choi
Bong-Kiun Kaang
Qiang Chang
Zhiping P. Pang
Richard L. Huganir
J. Julius Zhu
Source :
Genesdevelopment. 31(8)
Publication Year :
2017

Abstract

Here, Lim et al. present a fast cost-effective lentivirus-based rapid gene replacement method to interrogate the physiopathology of BRaf and ∼50 disease-linked BRaf mutants, including all CFC-linked mutants. This study establishes the first efficient procedure that permits large-scale functional analysis of human disease-linked mutations essential for precision medicine.

Details

ISSN :
15495477
Volume :
31
Issue :
8
Database :
OpenAIRE
Journal :
Genesdevelopment
Accession number :
edsair.doi.dedup.....c957a3ba4119ca0d613eedbdf86cf1f1