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Efficient and stable radiolabeling of polycyclic aromatic hydrocarbon assemblies: in vivo imaging of diesel exhaust particulates in mice
- Source :
- Chemical Communications. 55:447-450
- Publication Year :
- 2019
- Publisher :
- Royal Society of Chemistry (RSC), 2019.
-
Abstract
- As a robust radioanalytical method for tracking carbonaceous particulates in vivo, polycyclic aromatic hydrocarbons from diesel exhaust were labeled with a radioactive-iodine-tagged pyrene analogue. Single-photon emission computed tomography and biodistribution studies showed high uptake and slow clearance of this matter in the respiratory system, which may underlie its severe toxicity.
- Subjects :
- Biodistribution
Diesel exhaust
Polycyclic aromatic hydrocarbon
010402 general chemistry
complex mixtures
01 natural sciences
Catalysis
Mice
chemistry.chemical_compound
In vivo
Materials Chemistry
Animals
Tissue Distribution
Polycyclic Aromatic Hydrocarbons
Vehicle Emissions
Tomography, Emission-Computed, Single-Photon
chemistry.chemical_classification
Pyrenes
010405 organic chemistry
Chemistry
Radiochemistry
Metals and Alloys
General Chemistry
Particulates
Diesel Exhaust Particulate
0104 chemical sciences
Surfaces, Coatings and Films
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Pyrene
Preclinical imaging
Iodine
Subjects
Details
- ISSN :
- 1364548X and 13597345
- Volume :
- 55
- Database :
- OpenAIRE
- Journal :
- Chemical Communications
- Accession number :
- edsair.doi.dedup.....c9554a0f24ea8b8eccf8d2343c6dbd56