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Pituicytoma-An outlook on possible targeted therapies
- Source :
- CNS Neuroscience & Therapeutics. 23:620-626
- Publication Year :
- 2017
- Publisher :
- Wiley, 2017.
-
Abstract
- SummaryIntroduction Pituicytoma is a rare neoplasm of the sella region. Tumor resection is the primary treatment option, but remains subtotal due to excessive bleeding in many cases. The search for alternative or additional treatment regimens is necessary. Aims We aimed to determine the receptor expression of pituicytoma to find alternatives or supplements to surgical therapy in the use of targeted therapies. Methods Pituicytoma samples were collected from three institutions between 2006 and 2015 and were stained for vascular endothelial growth factors (VEGF), thyroid transcription factor (TTF1), and somatostatin receptors (SSTR 2/3/5). The stains were classified from 0=no staining to +++=strong staining. A complementary retrospective analysis of the patient charts regarding sex, age, and primary symptoms, pituitary function, and perioperative complications was performed. Results Ten samples were analyzed; mean patient age was 57.8 years SD 16.3 years. Seven samples were acquired from male patients (one relapse) and three from female. All tumors stained strongly positive (+++) for VEGF-R. Six samples stained positive for TTF1. As for somatostatin receptors, three samples were slightly positive for SSTR 2; seven were negative. SSTR 3 was + in one, three were ++, three were +++, and three were 0. SSTR 5 stained +++ in 1, ++ in 5, + in 1, and 0 in three patients. Conclusions Pituicytomas were generally positive for VEGFR and showed regular expression of SSTR 3 and 5 indicating a possible treatment option through targeted therapies in cases where resection remains insufficient. Further research is necessary as to whether tumor growth can be inhibited using these pathways.
- Subjects :
- Adult
Male
Vascular Endothelial Growth Factor A
Pathology
medicine.medical_specialty
Receptor expression
medicine.medical_treatment
030209 endocrinology & metabolism
Pituitary neoplasm
Targeted therapy
Young Adult
03 medical and health sciences
Postoperative Complications
0302 clinical medicine
Physiology (medical)
medicine
Humans
Neoplasm
Pituitary Neoplasms
Pharmacology (medical)
Receptors, Somatostatin
Intraoperative Complications
Aged
Retrospective Studies
Pharmacology
Somatostatin receptor
business.industry
Original Articles
Perioperative
Middle Aged
medicine.disease
DNA-Binding Proteins
Psychiatry and Mental health
Vascular endothelial growth factor A
Female
Neoplasm Recurrence, Local
business
030217 neurology & neurosurgery
Pituicytoma
Transcription Factors
Subjects
Details
- ISSN :
- 17555930
- Volume :
- 23
- Database :
- OpenAIRE
- Journal :
- CNS Neuroscience & Therapeutics
- Accession number :
- edsair.doi.dedup.....c954bbd093b128b372668d663950715d