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Remodeling the Integration of Lipid Metabolism Between Liver and Adipose Tissue by Dietary Methionine Restriction in Rats

Authors :
Daorong Feng
Desiree Wanders
Sujoy Ghosh
Jeffrey E. Pessin
Amanda Laque
Thomas W. Gettys
Barbara E. Hasek
Jeho Shin
Nancy T. Van
Matthew W. Hulver
Anik Boudreau
Laura K. Stewart
Kirsten P. Stone
Source :
Diabetes
Publication Year :
2013
Publisher :
American Diabetes Association, 2013.

Abstract

Dietary methionine restriction (MR) produces an integrated series of biochemical and physiological responses that improve biomarkers of metabolic health, limit fat accretion, and enhance insulin sensitivity. Using transcriptional profiling to guide tissue-specific evaluations of molecular responses to MR, we report that liver and adipose tissue are the primary targets of a transcriptional program that remodeled lipid metabolism in each tissue. The MR diet produced a coordinated downregulation of lipogenic genes in the liver, resulting in a corresponding reduction in the capacity of the liver to synthesize and export lipid. In contrast, the transcriptional response in white adipose tissue (WAT) involved a depot-specific induction of lipogenic and oxidative genes and a commensurate increase in capacity to synthesize and oxidize fatty acids. These responses were accompanied by a significant change in adipocyte morphology, with the MR diet reducing cell size and increasing mitochondrial density across all depots. The coordinated transcriptional remodeling of lipid metabolism between liver and WAT by dietary MR produced an overall reduction in circulating and tissue lipids and provides a potential mechanism for the increase in metabolic flexibility and enhanced insulin sensitivity produced by the diet.

Details

ISSN :
1939327X and 00121797
Volume :
62
Database :
OpenAIRE
Journal :
Diabetes
Accession number :
edsair.doi.dedup.....c94bf6ca9050985065dceb3cdb3f2159
Full Text :
https://doi.org/10.2337/db13-0501