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Treatment Paradigms for Retinal and Macular Diseases Using 3-D Retina Cultures Derived From Human Reporter Pluripotent Stem Cell Lines
- Source :
- Investigative Ophthalmology & Visual Science
- Publication Year :
- 2016
- Publisher :
- Association for Research in Vision and Ophthalmology (ARVO), 2016.
-
Abstract
- We discuss the use of pluripotent stem cell lines carrying fluorescent reporters driven by retinal promoters to derive three-dimensional (3-D) retina in culture and how this system can be exploited for elucidating human retinal biology, creating disease models in a dish, and designing targeted drug screens for retinal and macular degeneration. Furthermore, we realize that stem cell investigations are labor-intensive and require extensive resources. To expedite scientific discovery by sharing of resources and to avoid duplication of efforts, we propose the formation of a Retinal Stem Cell Consortium. In the field of vision, such collaborative approaches have been enormously successful in elucidating genetic susceptibility associated with age-related macular degeneration.
- Subjects :
- Pluripotent Stem Cells
0301 basic medicine
Retinal degeneration
Cellular differentiation
Retinal Pigment Epithelium
Biology
human retina development
Retina
drug discovery
Cell Line
Tissue Culture Techniques
Macular Degeneration
03 medical and health sciences
chemistry.chemical_compound
Genes, Reporter
disease modeling
medicine
Animals
Humans
Induced pluripotent stem cell
next generation sequencing
Retinal pigment epithelium
Special Issue
Gene Expression Profiling
Retinal Degeneration
chemical screens
three-dimensional organoid culture
Cell Differentiation
Retinal
Anatomy
Macular degeneration
medicine.disease
photoreceptor
3. Good health
Disease Models, Animal
030104 developmental biology
medicine.anatomical_structure
chemistry
fluorescent reporter
Stem cell
transcriptome
Neuroscience
high throughput screening
Retinal Neurons
Subjects
Details
- ISSN :
- 15525783
- Volume :
- 57
- Database :
- OpenAIRE
- Journal :
- Investigative Opthalmology & Visual Science
- Accession number :
- edsair.doi.dedup.....c949fc6e7c753abb8b85da886258ed34