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Effects of Lomefloxacin and Sparfloxacin on Human Platelet Aggregation
- Source :
- Journal of Chemotherapy. 7:420-423
- Publication Year :
- 1995
- Publisher :
- Informa UK Limited, 1995.
-
Abstract
- Platelet aggregation is inhibited by high concentrations of most antibiotics. For this reason it is important to evaluate the effects of new antimicrobial agents on platelet aggregation. Lomefloxacin and sparfloxacin are new difluorinated quinolone antimicrobial agents. The aim of this work was to evaluate in vitro the effects of lomefloxacin and sparfloxacin on adenosinediphosphate (ADP) and collagen-induced human platelet aggregation. Our data showed that both antibiotics (lomefloxacin and sparfloxacin) at therapeutic doses did not inhibit in vitro human platelet aggregation. Lomefloxacin, only at the highest tested concentration (1 mg/ml), which is far higher than the clinically achievable one, significantly (P < 0.05) inhibited collagen-induced platelet aggregation. Sparfloxacin also caused inhibition of collagen and ADP-induced human platelet aggregation only at the highest tested concentration (0.01 mg/ml), which is higher than that reached in vivo. These findings suggest that therapeutic doses of lomefloxacin and sparfloxacin do not affect human platelet aggregation.
- Subjects :
- Adult
Male
Platelet Aggregation
medicine.drug_class
Antibiotics
Quinolones
Pharmacology
Anti-Infective Agents
Reference Values
In vivo
medicine
Humans
Pharmacology (medical)
Platelet
Aged
Antibacterial agent
Dose-Response Relationship, Drug
Chemistry
Middle Aged
Quinolone
Antimicrobial
Adenosine Diphosphate
Infectious Diseases
Sparfloxacin
Oncology
Lomefloxacin
Collagen
Platelet Aggregation Inhibitors
Fluoroquinolones
medicine.drug
Subjects
Details
- ISSN :
- 19739478 and 1120009X
- Volume :
- 7
- Database :
- OpenAIRE
- Journal :
- Journal of Chemotherapy
- Accession number :
- edsair.doi.dedup.....c9475a53b17a945a6be464cdc0da58a0