Back to Search
Start Over
Nuclear Speckle RNA Binding Proteins Remodel Alternative Splicing and the Non-coding Arabidopsis Transcriptome to Regulate a Cross-Talk Between Auxin and Immune Responses
- Source :
- Frontiers in Plant Science, Frontiers in Plant Science, Frontiers, 2018, 9, ⟨10.3389/fpls.2018.01209⟩, Frontiers in Plant Science, Frontiers, 2018, 9, pp.1209. ⟨10.3389/fpls.2018.01209⟩, Frontiers in Plant Science, Vol 9 (2018), Frontiers in Plant Science, 2018, 9, pp.1209. ⟨10.3389/fpls.2018.01209⟩, CONICET Digital (CONICET), Consejo Nacional de Investigaciones Científicas y Técnicas, instacron:CONICET, Frontiers in Plant Science (9), 1-13. (2018)
- Publication Year :
- 2018
- Publisher :
- HAL CCSD, 2018.
-
Abstract
- Nuclear speckle RNA binding proteins (NSRs) act as regulators of alternative splicing (AS) and auxin-regulated developmental processes such as lateral root formation in Arabidopsis thaliana. These proteins were shown to interact with specific alternatively spliced mRNA targets and at least with one structured lncRNA, named Alternative Splicing Competitor RNA. Here, we used genome-wide analysis of RNAseq to monitor the NSR global role on multiple tiers of gene expression, including RNA processing and AS. NSRs affect AS of 100s of genes as well as the abundance of lncRNAs particularly in response to auxin. Among them, the FPA floral regulator displayed alternative polyadenylation and differential expression of antisense COOLAIR lncRNAs in nsra/b mutants. This may explains the early flowering phenotype observed in nsra and nsra/b mutants. GO enrichment analysis of affected lines revealed a novel link of NSRs with the immune response pathway. A RIP-seq approach on an NSRa fusion protein in mutant background identified that lncRNAs are privileged direct targets of NSRs in addition to specific AS mRNAs. The interplay of lncRNAs and AS mRNAs in NSR-containing complexes may control the crosstalk between auxin and the immune response pathway. Fil: Bazin, Jérémie. Universite Paris-sud Xi; Fil: Romero, Natali. Universite Paris-sud Xi; Fil: Rigo, Richard. Universite Paris-sud Xi; Fil: Charon, Celine. Universite Paris-sud Xi; Fil: Blein, Thomas. Universite Paris-sud Xi; Fil: Ariel, Federico Damian. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Agrobiotecnología del Litoral. Universidad Nacional del Litoral. Instituto de Agrobiotecnología del Litoral; Argentina Fil: Crespi, Martin. Universite Paris-sud Xi
- Subjects :
- 0106 biological sciences
0301 basic medicine
Polyadenylation
RNA-binding protein
AUXIN
Plant Science
RNA binding proteins
RNP complexes
alternative splicing
immune response
auxin
lcsh:Plant culture
Biology
01 natural sciences
purl.org/becyt/ford/1 [https]
Ciencias Biológicas
03 medical and health sciences
IMMUNE RESPONSE
Gene expression
[SDV.BV]Life Sciences [q-bio]/Vegetal Biology
lcsh:SB1-1110
ALTERNATIVE SPLICING
purl.org/becyt/ford/1.6 [https]
Gene
Lateral root formation
ComputingMilieux_MISCELLANEOUS
Original Research
Alternative splicing
RNA
Bioquímica y Biología Molecular
Cell biology
RNA BINDING PROTEINS
030104 developmental biology
RNA splicing
CIENCIAS NATURALES Y EXACTAS
RNP COMPLEXES
010606 plant biology & botany
Subjects
Details
- Language :
- English
- ISSN :
- 1664462X
- Database :
- OpenAIRE
- Journal :
- Frontiers in Plant Science, Frontiers in Plant Science, Frontiers, 2018, 9, ⟨10.3389/fpls.2018.01209⟩, Frontiers in Plant Science, Frontiers, 2018, 9, pp.1209. ⟨10.3389/fpls.2018.01209⟩, Frontiers in Plant Science, Vol 9 (2018), Frontiers in Plant Science, 2018, 9, pp.1209. ⟨10.3389/fpls.2018.01209⟩, CONICET Digital (CONICET), Consejo Nacional de Investigaciones Científicas y Técnicas, instacron:CONICET, Frontiers in Plant Science (9), 1-13. (2018)
- Accession number :
- edsair.doi.dedup.....c9376613d5e1c7990eeecb74fc08a224