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Reproduction impairment and endocrine disruption in adult zebrafish (Danio rerio) after waterborne exposure to TBOEP
- Source :
- Aquatic toxicology (Amsterdam, Netherlands). 182
- Publication Year :
- 2016
-
Abstract
- Tris (2-butoxyethyl) phosphate (TBOEP) is widely used as a substitute of polybrominated diphenyl ethers (PBDEs). It has been frequently measured at concentrations of micrograms per liter (μg/L) in surface waters and waste water. However, limited information is available about the reproduction toxicology of TBOEP. In this study, adult zebrafish pairs were exposed to TBOEP at concentrations of 0, 5, 50, and 500μg/L for 21days. The effects on reproduction, hormone concentration, transcription of genes along the hypothalamic-pituitary-gonadal (HPG) axis, and gonadal development were investigated. After exposure to TBOEP, plasma concentrations of 17β-estradiol were significantly increased in both sexes of fish, while increase of testosterone was observed only in male fish. Transcription of genes along the HPG axis was significantly influenced by exposure to TBOEP in both male and female fish. Moreover, TBOEP decreases the average number of eggs production, as well as hatching success and survival rates in offspring. Histological examination shows inhibition of oocyte maturation in females and retardation spermiation in males, respectively. The results demonstrate that TBOEP could disturb the sex hormone balance by altering regulatory circuits of the HPG axis, affect gonadal development, eventually leading to disruption of reproductive performance and the development of progeny.
- Subjects :
- 0301 basic medicine
Male
endocrine system
medicine.medical_specialty
Hypothalamo-Hypophyseal System
Offspring
Health, Toxicology and Mutagenesis
Danio
Hypothalamic–pituitary–gonadal axis
010501 environmental sciences
Aquatic Science
Biology
Endocrine Disruptors
01 natural sciences
03 medical and health sciences
Random Allocation
Polybrominated diphenyl ethers
Organophosphorus Compounds
Internal medicine
Toxicity Tests
medicine
Animals
Gonadal Steroid Hormones
Gonads
Zebrafish
0105 earth and related environmental sciences
Dose-Response Relationship, Drug
Hatching
Reproduction
biology.organism_classification
030104 developmental biology
Endocrinology
Female
Development of the gonads
Biomarkers
Water Pollutants, Chemical
Hormone
Subjects
Details
- ISSN :
- 18791514
- Volume :
- 182
- Database :
- OpenAIRE
- Journal :
- Aquatic toxicology (Amsterdam, Netherlands)
- Accession number :
- edsair.doi.dedup.....c931a976c94d406c1bd8389ec1b90d62