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A comparison of health utility measures for the evaluation of multiple sclerosis treatments
- Publication Year :
- 2005
- Publisher :
- BMJ Group, 2005.
-
Abstract
- To evaluate the practical application and psychometric properties of three health utility measures in a sample of MS patients with a broad range of neurological disability as measured by the Extended Disability Status Scale (EDSS).Patients randomly selected from two MS clinic registries were assessed using standard clinical methods and completed three generic measures of health utility (EQ-5D, HUI Mark III, SF-6D). The proportion of missing data, test/retest reliability, and construct validity of each health utility measure were examined.The assessments were completed by 187 patients. Less than 10% of data were missing for the subscales of the SF-6D (3.2%), HUI Mark III (1.6%), and EQ-5D (or =7.5%). Severely disabled patients were more likely to omit physical function questions for the SF-6D (20%), and EQ-5D (43%). Retest reliability for the SF-6D (ICC = 0.83), EQ-5D (ICC = 0.81), and HUI Mark III (ICC = 0.87) were adequate for population surveys. Correlations between assessment of clinical function and each health utility measure were strongest for the HUI Mark III (HUI Mark III EDSS rho = -0.77, HUI Mark III ambulation index rho = -0.76, HUI Mark III timed 25 foot walk rho = -0.73, HUI Mark III nine hole peg test rho = -0.65).The health utility measures were generally feasible and reliable but the HUI Mark III demonstrated highest concordance with the EDSS across the full range of neurological disability. Of the three measures studied, the HUI Mark III may be the most appropriate for cost effectiveness evaluations of MS therapies.
- Subjects :
- Paper
Adult
Male
medicine.medical_specialty
Multiple Sclerosis
Psychometrics
Cost effectiveness
Cross-sectional study
Concordance
Disability Evaluation
Quality of life (healthcare)
Adjuvants, Immunologic
medicine
Health Status Indicators
Humans
Aged
Aged, 80 and over
business.industry
Interferon beta-1a
Construct validity
Reproducibility of Results
Glatiramer Acetate
Interferon-beta
Middle Aged
Missing data
Surgery
Psychiatry and Mental health
Cross-Sectional Studies
Treatment Outcome
Physical therapy
Quality of Life
Female
Neurology (clinical)
business
Peptides
medicine.drug
Interferon beta-1b
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....c91ffb80e486e0561b53e982eb7ce596