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Antifibrotic Effect of Boric Acid in Rats with Epidural Fibrosis
- Source :
- World Neurosurgery. 122:e989-e994
- Publication Year :
- 2019
- Publisher :
- Elsevier BV, 2019.
-
Abstract
- WOS: 000457328100119<br />PubMed ID: 30399469<br />BACKGROUND: Epidural fibrosis is a major problem after spine surgery, with some patients having recurrent symptoms secondary to excessive formation of scar tissue resulting in neurologic compression. We used a rat laminectomy model to determine if topical application of boric acid could be helpful in the prevention of epidural fibrosis. METHODS: Rats were randomly assigned to 2 control and 2 experimental groups (n = 8 for each group). The negative control group received no surgery, and the positive control group underwent laminectomy only. Experimental groups were classified according to the study agents applied onto the dura mater after laminectomy at the L3 level: 2.5% boric acid solution and 5% boric acid solution. The extent of epidural fibrosis was assessed 4 weeks later macroscopically and histopathologically. RESULTS: Boric acid reduced epidural fibrosis in rats after laminectomy. The effect of 5% boric acid solution was more pronounced (P < 0.05) compared with the 2.5% solution. CONCLUSIONS: The antifibrotic effect of boric acid solution for the prevention of epidural fibrosis suggests that boric acid should be further evaluated in future studies for the prevention of epidural fibrosis.
- Subjects :
- Epidural Space
Male
medicine.medical_specialty
Future studies
medicine.medical_treatment
Dura mater
Scar tissue
Positive control
Gastroenterology
Boric acid
Cicatrix
Random Allocation
03 medical and health sciences
chemistry.chemical_compound
Postoperative Complications
0302 clinical medicine
Spine surgery
Boric Acids
Internal medicine
medicine
Animals
Rats, Wistar
Epidural fibrosis
Dose-Response Relationship, Drug
business.industry
Laminectomy
Fibrosis
Antifibrinolytic Agents
Rats
Treatment Outcome
medicine.anatomical_structure
chemistry
030220 oncology & carcinogenesis
Surgery
Neurology (clinical)
business
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 18788750
- Volume :
- 122
- Database :
- OpenAIRE
- Journal :
- World Neurosurgery
- Accession number :
- edsair.doi.dedup.....c90459477de3924be04de90221262720