Back to Search
Start Over
Requirement of H-2 heterozygosity for autoimmunity in (NZB × NZW)F1 hybrid mice
- Source :
- European Journal of Immunology. 16:1631-1633
- Publication Year :
- 1986
- Publisher :
- Wiley, 1986.
-
Abstract
- In the F1 hybrid of autoimmune New Zealand Black (NZB) and phenotypically normal New Zealand White (NZW) mice, there occurs a severe systemic lupus erythematosus (SLE)-like autoimmune disease more fulminant than that found in the parental NZB mice. To determine the role of the H-2 complex in the pathogenesis of autoimmune disease of the (NZB X NZW)F1 hybrid, we developed H-2-congenic NZB (NZB.H-2z) and NZW (NZW.H-2d) strains, and compared the degree of autoimmune features between congenic H-2d/H-2d and H-2z/H-2z homozygous F1 hybrids and the original H-2d/H-2z heterozygous (NZB X NZW)F1 hybrid. We found that autoimmune features such as productions of IgG class anti-DNA antibodies and retroviral gp70 immune complexes and the development of renal disease were to a great extent reduced in both H-2 homozygous F1 hybrids, as compared with the H-2 heterozygous (NZB X NZW)F1 hybrid. It would thus appear that the heterozygosity of H-2d haplotype derived from NZB and H-2z from NZW is essential for the autoimmune disease characteristic of the (NZB X NZW)F1 hybrid.
- Subjects :
- Heterozygote
Receptors, Antigen, T-Cell, alpha-beta
Immunology
Receptors, Antigen, T-Cell
Congenic
chemical and pharmacologic phenomena
urologic and male genital diseases
medicine.disease_cause
Immunoglobulin G
Autoimmune Diseases
Autoimmunity
Pathogenesis
Loss of heterozygosity
Mice
Immune system
immune system diseases
medicine
Animals
Immunology and Allergy
skin and connective tissue diseases
Autoimmune disease
Mice, Inbred NZB
biology
H-2 Antigens
DNA
medicine.disease
Peptide Fragments
biology.protein
Hybridization, Genetic
Antibody
Subjects
Details
- ISSN :
- 15214141 and 00142980
- Volume :
- 16
- Database :
- OpenAIRE
- Journal :
- European Journal of Immunology
- Accession number :
- edsair.doi.dedup.....c901af26f8aa18a8bc75680126aa553e