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Rapid microfluidic platform for screening and enrichment of cells secreting virus neutralizing antibodies

Authors :
Weikang Nicholas Lin
Matthew Zirui Tay
Joel Xu En Wong
Chia Yin Lee
Siew-Wai Fong
Cheng-I Wang
Lisa Fong Poh Ng
Laurent Renia
Chia-Hung Chen
Lih Feng Cheow
Source :
Lab on a Chip. 22:2578-2589
Publication Year :
2022
Publisher :
Royal Society of Chemistry (RSC), 2022.

Abstract

As part of the body's immune response, antibodies (Abs) have the ability to neutralize pathogenic viruses to prevent infection. To screen for neutralizing Abs (nAbs) from the immune repertoire, multiple screening techniques have been developed. However, conventional methods have a trade-off between screening throughput and the ability to screen for nAbs

Details

ISSN :
14730189 and 14730197
Volume :
22
Database :
OpenAIRE
Journal :
Lab on a Chip
Accession number :
edsair.doi.dedup.....c8ff31531ad0fcf66cf94a4ef1c2c64d