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Association of Dopamine Transporter Loss in the Orbitofrontal and Dorsolateral Prefrontal Cortices With Methamphetamine-Related Psychiatric Symptoms
- Source :
- American Journal of Psychiatry. 160:1699-1701
- Publication Year :
- 2003
- Publisher :
- American Psychiatric Association Publishing, 2003.
-
Abstract
- The authors examined dopamine transporter density in the orbitofrontal cortex, dorsolateral prefrontal cortex, and amygdala in methamphetamine users and assessed the relationship of these measures to the subjects' clinical characteristics.Positron emission tomography with [(11)C]WIN 35,428 was used to examine the regions of interest in 11 methamphetamine users and nine healthy comparison subjects. Psychiatric symptoms were evaluated with the Brief Psychiatric Rating Scale.Dopamine transporter density in the three regions studied was significantly lower in the methamphetamine users than in the comparison subjects. The lower dopamine transporter density in the orbitofrontal and dorsolateral prefrontal cortex was significantly correlated with the duration of methamphetamine use and the severity of psychiatric symptoms.Chronic methamphetamine use may cause dopamine transporter reduction in the orbitofrontal cortex, dorsolateral prefrontal cortex, and amygdala in the brain. Psychiatric symptoms in methamphetamine users may be attributable to the decrease in dopamine transporter density in the orbitofrontal cortex and the dorsolateral prefrontal cortex.
- Subjects :
- Adult
Male
medicine.medical_specialty
Amphetamine-Related Disorders
Prefrontal Cortex
Nerve Tissue Proteins
Dopamine agonist
Psychoses, Substance-Induced
Methamphetamine
Cocaine
Dopamine Uptake Inhibitors
Dopamine
Brief Psychiatric Rating Scale
medicine
Humans
Psychiatry
Prefrontal cortex
Dopamine transporter
Dopamine Plasma Membrane Transport Proteins
Membrane Glycoproteins
biology
business.industry
Membrane Transport Proteins
Amygdala
Frontal Lobe
Dorsolateral prefrontal cortex
Psychiatry and Mental health
medicine.anatomical_structure
biology.protein
Orbitofrontal cortex
business
Neuroscience
Tomography, Emission-Computed
medicine.drug
Subjects
Details
- ISSN :
- 15357228 and 0002953X
- Volume :
- 160
- Database :
- OpenAIRE
- Journal :
- American Journal of Psychiatry
- Accession number :
- edsair.doi.dedup.....c8f50b87d5e0162d0e483aa1c3cf6d85