Back to Search
Start Over
Impaired Geriatric 8 Score is Associated with Worse Survival after Radiotherapy in Older Patients with Cancer
- Source :
- Clinical Oncology, 33(4), E203-E210. ELSEVIER SCIENCE LONDON, Clinical oncology, 33(4), E203-E210. Elsevier Science, Clinical oncology (Royal College of Radiologists (Great Britain)), 33(4), e203-e210. W.B. Saunders Ltd, Clinical Oncology, 33(4), e203-e210. W.B. Saunders
- Publication Year :
- 2021
-
Abstract
- Aims: To investigate whether the Geriatric 8 (G8) score and the Timed Get Up and Go Test (TGUGT), together with clinical and demographic patient characteristics, are associated with survival and late toxicity after (chemo)radiation therapy, administered with curative intent in older patients with cancer.Materials and methods: Four hundred and two patients aged similar to 65 years (median age 72 years, range 65-96 years), diagnosed with either breast, non-small cell lung, prostate, head and neck, rectal or oesophageal cancer, and referred for curative (chemo)radiation therapy, took part in a multicentre prospective cohort study in eight radiotherapy centres in the Netherlands. The G8 and TGUGT scores were assessed before starting treatment. Other potential predictors and late toxicity were also recorded. Survival status and date of death, if applicable, were ascertained at the Dutch national death registry.Results: After 2.5 years, the overall survival was 83%. Survival was 87% for patients with high G8 scores and 55% for patients with low G8 scores (Log-rank P value < 0.0001). Survival was 77% for patients with good TGUGT results and 50% for patients with poor TGUGT results (Log-rank P value < 0.001). In multi-variable analysis, in addition to age and type of primary tumour, the association of the G8 score with overall survival remained, with a hazard ratio of 2.1 (95% confidence interval 1.2-3.8) for low versus high scores.Conclusions: G8 was associated with overall survival in older patients with cancer irradiated with curative intent. This association was independent of the predictive value of age and primary tumour. (C) 2020 The Royal College of Radiologists. Published by Elsevier Ltd.
- Subjects :
- Male
Survival Status
medicine.medical_specialty
Get up and go test
medicine.medical_treatment
elderly
survival
030218 nuclear medicine & medical imaging
Late toxicity
03 medical and health sciences
0302 clinical medicine
Older patients
SDG 3 - Good Health and Well-being
Prostate
Neoplasms
Internal medicine
medicine
Humans
Radiology, Nuclear Medicine and imaging
Prospective Studies
Prospective cohort study
Geriatric Assessment
radiotherapy
Aged
Netherlands
Proportional Hazards Models
Cancer
G8
Aged, 80 and over
business.industry
TGUGT
medicine.disease
Radiation therapy
medicine.anatomical_structure
Oncology
030220 oncology & carcinogenesis
business
Subjects
Details
- Language :
- English
- ISSN :
- 09366555
- Volume :
- 33
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Clinical Oncology
- Accession number :
- edsair.doi.dedup.....c8e6cd4fe21b2b9dc77bce111655ea5c