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Reduced Numbers of Corticotropin-Releasing Hormone Neurons in Narcolepsy Type 1
- Source :
- Annals of Neurology, 91(2), 282-288. WILEY, Annals of Neurology, Annals of Neurology, 91, 282-288. John Wiley and Sons Inc.
- Publication Year :
- 2022
- Publisher :
- WILEY, 2022.
-
Abstract
- Narcolepsy type 1 (NT1) is a chronic sleep disorder correlated with loss of hypocretin(orexin). In NT1 post-mortem brains, we observed 88% reduction in corticotropin-releasing hormone (CRH)-positive neurons in the paraventricular nucleus (PVN) and significantly less CRH-positive fibers in the median eminence, while CRH-neurons in the locus coeruleus and thalamus, and other PVN neuronal populations were spared: i.e. vasopressin, oxytocin, tyrosine hydroxylase and thyrotropin releasing hormone-expressing neurons. Other hypothalamic cell groups, i.e. the suprachiasmatic, ventrolateral preoptic, infundibular and supraoptic nuclei and nucleus basalis of Meynert were unaffected. The surprising selective decrease in CRH-neurons provide novel targets for diagnostics and therapeutic interventions. This article is protected by copyright. All rights reserved.
- Subjects :
- Aged, 80 and over
Male
Neurons
endocrine system
Corticotropin-Releasing Hormone
Hypothalamus
Median Eminence
Cell Count
Middle Aged
Immunohistochemistry
Neurology
nervous system
Humans
Female
Locus Coeruleus
Neurology (clinical)
hormones, hormone substitutes, and hormone antagonists
Aged
Narcolepsy
Paraventricular Hypothalamic Nucleus
Subjects
Details
- Language :
- English
- ISSN :
- 03645134
- Database :
- OpenAIRE
- Journal :
- Annals of Neurology, 91(2), 282-288. WILEY, Annals of Neurology, Annals of Neurology, 91, 282-288. John Wiley and Sons Inc.
- Accession number :
- edsair.doi.dedup.....c8c3dd1eb483f2902fb3a58634533766