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The cost-effectiveness of prophylaxis strategies for individuals with advanced HIV starting treatment in Africa

Authors :
Walker, SM
Cox, E
Revill, P
Musiime, V
Bwakura‐Dangarembizi, M
Mallewa, J
Cheruiyot, P
Maitland, K
Ford, N
Gibb, DM
Walker, AS
Soares, M
Mugyenyi, P
Kityo, C
Wavamunno, P
Nambi, E
Ocitti, P
Ndigendawani, M
Kabahenda, S
Kemigisa, M
Acen, J
Olebo, D
Mpamize, G
Amone, A
Okweny, D
Mbonye, A
Nambaziira, F
Rweyora, A
Kangah, M
Kabaswahili, V
Abach, J
Abongomera, G
Omongin, J
Aciro, I
Philliam, A
Arach, B
Ocung, E
Amone, G
Miles, P
Adong, C
Tumsuiime, C
Kidega, P
Otto, B
Apio, F
Baleeta, K
Mukuye, A
Abwola, M
Ssennono, F
Baliruno, D
Tuhirwe, S
Namisi, R
Kigongo, F
Kikyonkyo, D
Mushahara, F
Tusiime, J
Musiime, A
Nankya, A
Atwongyeire, D
Sirikye, S
Mula, S
Noowe, N
Lugemwa, A
Kasozi, M
Mwebe, S
Atwine, L
Senkindu, T
Natuhurira, T
Katemba, C
Ninsiima, E
Acaku, M
Kyomuhangi, J
Ankunda, R
Tukwasibwe, D
Ayesiga, L
Hakim, J
Nathoo, K
Reid, A
Chidziva, E
Mhute, T
Tinago, GC
Bhiri, J
Mudzingwa, S
Phiri, M
Steamer, J
Nhema, R
Warambwa, C
Musoro, G
Mutsai, S
Nemasango, B
Moyo, C
Chitongo, S
Rashirai, K
Vhembo, S
Mlambo, B
Nkomani, S
Ndemera, B
Willard, M
Berejena, C
Musodza, Y
Matiza, P
Mudenge, B
Guti, V
Etyang, A
Agutu, C
Berkley, J
Njuguna, P
Mwaringa, S
Etyang, T
Awuondo, K
Wale, S
Shangala, J
Kithunga, J
Mwarumba, S
Said Maitha, S
Mutai, R
Lozi Lewa, M
Mwambingu, G
Mwanzu, A
Kalama, C
Latham, H
Shikuku, J
Fondo, A
Njogu, A
Khadenge, C
Mwakisha, B
Siika, A
Wools‐Kaloustian, K
Nyandiko, W
Sudoi, A
Wachira, S
Meli, B
Karoney, M
Nzioka, A
Tanui, M
Mokaya, M
Ekiru, W
Mboya, C
Mwimali, D
Mengich, C
Choge, J
Injera, W
Njenga, K
Cherutich, S
Anyango Orido, M
Omondi Lwande, G
Rutto, P
Mudogo, A
Kutto, I
Shali, A
Jaika, L
Jerotich, H
Pierre, M
Kaunda, S
Van Oosterhout, J
O'Hare, B
Heydermann, R
Gonzalez, C
Dzabala, N
Kelly, C
Denis, B
Selemani, G
Nyondo Mipando, L
Chirwa, E
Banda, P
Mvula, L
Msuku, H
Ziwoya, M
Manda, Y
Nicholas, S
Masesa, C
Mwalukomo, T
Makhaza, L
Sheha, I
Bwanali, J
Limbuni, M
Gibb, D
Thomason, M
Pett, S
Szubert, A
Griffiths, A
Wilkes, H
Rajapakse, C
Spyer, M
Prendergast, A
Klein, N
Rauchenberger, M
Van Looy, N
Little, E
Fairbrother, K
Cowan, F
Seeley, J
Bernays, S
Kawuma, R
Mupambireyi, Z
Kyomuhendo, F
Nakalanzi, S
Peshu, J
Ndaa, S
Chabuka, J
Mkandawire, N
Matandika, L
Kapuya, C
Weller, I
Malianga, E
Mwansambo, C
Miiro, F
Elyanu, P
Bukusi, E
Katabira, E
Mugurungi, O
Peto, T
Musoke, P
Matenga, J
Phiri, S
Lyall, H
Johnston, V
Fitzgerald, F
Post, F
Ssali, F
Arenas‐Pinto, A
Turkova, A
Bamford, A
Academic Medical Center
DiFDMRCWellcome Trust
Source :
Journal of the International AIDS Society, Journal of the International AIDS Society, 23(3):e25469. International AIDS Society
Publication Year :
2020

Abstract

Introduction: Many HIV-positive individuals in Africa have advanced disease when initiating antiretroviral therapy (ART) so have high risks of opportunistic infections and death. The REALITY trial found that an enhanced-prophylaxis package including fluconazole reduced mortality by 27% in individuals starting ART with CD4

Subjects

Subjects :
Male
Antifungal Agents
Cost effectiveness
Cost-Benefit Analysis
Human immunodeficiency virus (HIV)
HIV Infections
medicine.disease_cause
Cohort Studies
0302 clinical medicine
late‐presenters
fluconazole
Advanced disease
Global health
030212 general & internal medicine
Child
Research Articles
health care economics and organizations
education.field_of_study
cost‐effectiveness
3. Good health
Infectious Diseases
Child, Preschool
Female
Quality-Adjusted Life Years
prophylaxis
0305 other medical science
Post-Exposure Prophylaxis
medicine.drug
Research Article
Adult
medicine.medical_specialty
Tuberculosis
Antigens, Fungal
Adolescent
Cryptococcal antigen
Anti-HIV Agents
Population
late-presenters
1117 Public Health and Health Services
03 medical and health sciences
medicine
Humans
education
cost-effectiveness
030505 public health
AIDS-Related Opportunistic Infections
business.industry
Public Health, Environmental and Occupational Health
HIV
1103 Clinical Sciences
medicine.disease
CD4 Lymphocyte Count
Cryptococcus
Emergency medicine
Africa
business
Fluconazole
1199 Other Medical and Health Sciences

Details

Language :
English
ISSN :
17582652
Volume :
23
Issue :
3
Database :
OpenAIRE
Journal :
Journal of the International AIDS Society
Accession number :
edsair.doi.dedup.....c8bf3420fb8dc508bbfcb21f86ed4cc3

Tools

Authors Abstract Subjects Details