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Adverse effects of perinatal nicotine exposure on reproductive outcomes
- Source :
- Reproduction, Reproduction, BioScientifica, 2015, 150 (6), pp.R185-R193. ⟨10.1530/REP-15-0295⟩, Paediatrics Publications, Reproduction, 2015, 150 (6), pp.R185-R193. ⟨10.1530/REP-15-0295⟩
- Publication Year :
- 2015
- Publisher :
- HAL CCSD, 2015.
-
Abstract
- Nicotine exposure during pregnancy through cigarette smoking, nicotine replacement therapies or e-cigarette use continues to be a widespread public health problem, impacting both fetal and postnatal health. Yet, at this time, there remains limited data regarding the safety and efficacy in using these nicotine products during pregnancy. Notably, reports assessing the effect of nicotine exposure on postnatal health outcomes in humans, including reproductive health, are severely lacking. Our current understanding regarding the consequences of nicotine exposure during pregnancy is limited to a few animal studies, which do not comprehensively address the underlying cellular mechanisms involved. This paper aims to critically review the current knowledge from human and animal studies regarding the direct and indirect effects (e.g. obesity) of maternal nicotine exposure, regardless of its source, on reproductive outcomes in pregnancy and postnatal life. Furthermore, this review highlights several key cellular mechanisms involved in these adverse reproductive deficits including oxidative stress, inflammation, and endoplasmic reticulum (ER) stress. By understanding the interplay of the cellular mechanisms involved, further strategies could be developed to prevent the reproductive abnormalities resulting from exposure to nicotinein uteroand influence informed clinical guidelines for pregnant women.
- Subjects :
- Embryology
medicine.medical_specialty
Nicotine
Smoking Prevention
Electronic Nicotine Delivery Systems
Bioinformatics
Risk Assessment
Toxicology
03 medical and health sciences
0302 clinical medicine
Endocrinology
Fetus
Pregnancy
Risk Factors
medicine
Animals
Humans
Nicotinic Agonists
Adverse effect
Maternal Behavior
030304 developmental biology
Reproductive health
Nicotine replacement
0303 health sciences
030219 obstetrics & reproductive medicine
business.industry
Public health
Smoking
Obstetrics and Gynecology
[SDV.BDLR]Life Sciences [q-bio]/Reproductive Biology
Cell Biology
medicine.disease
Endoplasmic Reticulum Stress
Tobacco Use Cessation Devices
3. Good health
Pregnancy Complications
Oxidative Stress
Reproductive Medicine
Prenatal Exposure Delayed Effects
Unfolded Protein Response
Female
Animal studies
Inflammation Mediators
business
medicine.drug
Subjects
Details
- Language :
- English
- ISSN :
- 14701626 and 17417899
- Database :
- OpenAIRE
- Journal :
- Reproduction, Reproduction, BioScientifica, 2015, 150 (6), pp.R185-R193. ⟨10.1530/REP-15-0295⟩, Paediatrics Publications, Reproduction, 2015, 150 (6), pp.R185-R193. ⟨10.1530/REP-15-0295⟩
- Accession number :
- edsair.doi.dedup.....c8b22c96259eced2429d23fcf889af96