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Can zinc protect cells from the cytotoxic effects of cobalt ions and nanoparticles derived from metal-on-metal joint arthroplasties?
- Source :
- Bone & Joint Research
- Publication Year :
- 2017
- Publisher :
- British Editorial Society of Bone & Joint Surgery, 2017.
-
Abstract
- Objectives Recently, high failure rates of metal-on-metal (MOM) hip implants have raised concerns of cobalt toxicity. Adverse reactions occur to cobalt nanoparticles (CoNPs) and cobalt ions (Co2+) during wear of MOM hip implants, but the toxic mechanism is not clear. Methods To evaluate the protective effect of zinc ions (Zn2+), Balb/3T3 mouse fibroblast cells were pretreated with 50 μM Zn2+ for four hours. The cells were then exposed to different concentrations of CoNPs and Co2+ for four hours, 24 hours and 48 hours. The cell viabilities, reactive oxygen species (ROS) levels, and inflammatory cytokines were measured. Results CoNPs and Co2+ can induce the increase of ROS and inflammatory cytokines, such as tumour necrosis factor α (TNF-α), interleukin-1β (IL-1β) and interleukin-6 (IL-6). However, Zn pretreatment can significantly prevent cytotoxicity induced by CoNPs and Co2+, decrease ROS production, and decrease levels of inflammatory cytokines in Balb/3T3 mouse fibroblast cells. Conclusion These results suggest that Zn pretreatment can provide protection against inflammation and cytotoxicity induced by CoNPs and Co2+ in Balb/3T3 cells. Cite this article: Y. Liu, H. Zhu, H. Hong, W. Wang, F. Liu. Can zinc protect cells from the cytotoxic effects of cobalt ions and nanoparticles derived from metal-on-metal joint arthroplasties? Bone Joint Res 2017;6:649–655. DOI: 10.1302/2046-3758.612.BJR-2016-0137.R2.
- Subjects :
- 0301 basic medicine
chemistry.chemical_element
Nanoparticle
02 engineering and technology
Zinc
COBALT TOXICITY
Metal
03 medical and health sciences
Cobalt Nanoparticles
Protective Effects
Orthopedics and Sports Medicine
Research
Cobalt Ions
021001 nanoscience & nanotechnology
030104 developmental biology
chemistry
visual_art
visual_art.visual_art_medium
Cobalt ions
Surgery
Cobalt Cytotoxicity
0210 nano-technology
Cobalt
Nuclear chemistry
Subjects
Details
- ISSN :
- 20463758
- Volume :
- 6
- Database :
- OpenAIRE
- Journal :
- Bone & Joint Research
- Accession number :
- edsair.doi.dedup.....c89fd72b5e8a5eaf347baf20e46782cb