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Inhaled corticosteroids reduce senescence in endothelial progenitor cells from patients with COPD

Authors :
Koralia Paschalaki
Christos Rossios
Charis Pericleous
Mairi MacLeod
Stephen Rothery
Gavin C Donaldson
Jadwiga A Wedzicha
Vassilis Gorgoulis
Anna M Randi
Peter J Barnes
Source :
Thorax. 77:616-620
Publication Year :
2022
Publisher :
BMJ, 2022.

Abstract

Cellular senescence contributes to the pathophysiology of chronic obstructive pulmonary disease (COPD) and cardiovascular disease. Using endothelial colony-forming-cells (ECFC), we have demonstrated accelerated senescence in smokers and patients with COPD compared with non-smokers. Subgroup analysis suggests that ECFC from patients with COPD on inhaled corticosteroids (ICS) (n=14; eight on ICS) exhibited significantly reduced senescence (Senescence-associated-beta galactosidase activity, p21CIP1), markers of DNA damage response (DDR) and IFN-γ-inducible-protein-10 compared with patients with COPD not on ICS. In vitro studies using human-umbilical-vein-endothelial-cells showed a protective effect of ICS on the DDR, senescence and apoptosis caused by oxidative stress, suggesting a protective molecular mechanism of action of corticosteroids on endothelium.

Details

ISSN :
14683296 and 00406376
Volume :
77
Database :
OpenAIRE
Journal :
Thorax
Accession number :
edsair.doi.dedup.....c89c41632eb6c331ce9199dc8fffb3c9
Full Text :
https://doi.org/10.1136/thoraxjnl-2020-216807