Back to Search
Start Over
Gender-Specific Response in Pain and Function to Biologic Treatment of Knee Osteoarthritis: A Gender-Bias-Mitigated, Observational, Intention-to-Treat Study at Two Years
- Source :
- Stem Cells International, Vol 2021 (2021), Stem Cells International
- Publication Year :
- 2021
- Publisher :
- Hindawi, 2021.
-
Abstract
- Knee osteoarthritis is a major cause of disability worldwide. Newer modalities of treatment with less morbidity, such as intra-articular injection of microfragmented fat (MFAT), are showing promise. We report on our novel observation that women show a greater improvement in pain and function to MFAT than men. Traditionally, women have been underrepresented in studies and studies with both sexes regularly fail to analyze the results by sex. To mitigate for this bias and quantify it, we describe a technique using reproducible statistical analysis and replicable results with Open Access statistical software R to calculate the magnitude of this difference. Genetic, hormonal, environmental, and age factors play a role in our observed difference between the sexes. There is a need for further studies to identify the molecular basis for this difference and be able to utilize it to improve outcome for both women and men.
- Subjects :
- medicine.medical_specialty
Article Subject
MEDLINE
Osteoarthritis
Biologic treatment
03 medical and health sciences
0302 clinical medicine
medicine
Gender bias
Statistical analysis
030212 general & internal medicine
Molecular Biology
Internal medicine
030222 orthopedics
Intention-to-treat analysis
Modalities
business.industry
Cell Biology
medicine.disease
RC31-1245
Settore MED/34 - Medicina Fisica e Riabilitativa
Knee osteoarthritis
Physical therapy
Observational study
business
Research Article
Subjects
Details
- Language :
- English
- ISSN :
- 1687966X
- Database :
- OpenAIRE
- Journal :
- Stem Cells International
- Accession number :
- edsair.doi.dedup.....c898f6bf5d5d6adb5a7538e2eb914775
- Full Text :
- https://doi.org/10.1155/2021/6648437