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Protective effect of edible marine algae, Laminaria japonica and Porphyra haitanensis, on subchronic toxicity in rats induced by inorganic arsenic
- Source :
- Biological trace element research. 154(3)
- Publication Year :
- 2013
-
Abstract
- Arsenic, a potent environmental toxic agent, causes various hazardous effects on human health. This study was performed to evaluate the protective effects of edible marine algae, Laminaria japonica and Porphyra haitanensis, on subchronic stress of rats induced by arsenic trioxide (As2O3). The co-treatment of marine algae could slightly increase the growth rates of body weights compared to the As2O3-treated group. The marine algae application restored liver and renal function by preventing the increment in the activities of alanine transaminase and alkaline phosphatase, and the levels of total protein, blood urea nitrogen, and creatinine. The increase in the contents of total cholesterol, triglyceride, and low density lipoprotein cholesterol, and decrease in the contents of high density lipoprotein cholesterol were observed in algae co-treated groups which indicated that marine algae could reverse the abnormal lipid metabolisms induced by arsenic. Moreover, these algae could protect the rats from lipid peroxidation by restoring the depletion of superoxide dismutase and glutathione peroxidase activities and sulfhydryl group contents, and lowering the enhanced malondialdehyde contents. Therefore, evidences indicate that L. japonica and P. haitanensis can serve as an effective regimen for treating arsenic poisoning.
- Subjects :
- Male
Endocrinology, Diabetes and Metabolism
Clinical Biochemistry
Arsenic poisoning
Biochemistry
Arsenicals
Blood Urea Nitrogen
Lipid peroxidation
chemistry.chemical_compound
Arsenic Trioxide
Malondialdehyde
Arsenic trioxide
chemistry.chemical_classification
Glutathione peroxidase
Alanine Transaminase
Oxides
General Medicine
Cholesterol
Treatment Outcome
Creatinine
Female
Laminaria
chemistry.chemical_element
Biology
Protective Agents
Inorganic Chemistry
Algae
Arsenic Poisoning
medicine
Animals
Humans
Rats, Wistar
Arsenic
Triglycerides
Porphyra
Glutathione Peroxidase
Arsenic toxicity
Superoxide Dismutase
Biochemistry (medical)
Cholesterol, HDL
Cholesterol, LDL
biology.organism_classification
medicine.disease
Alkaline Phosphatase
Lipid Metabolism
Rats
chemistry
Porphyra haitanensis
Lipid Peroxidation
Subjects
Details
- ISSN :
- 15590720
- Volume :
- 154
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Biological trace element research
- Accession number :
- edsair.doi.dedup.....c88d3207a6e3c93125c5c4b3da5e8729