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IMRT and 3D conformal radiotherapy with or without elective nodal irradiation in locally advanced NSCLC: A direct comparison of PET-based treatment planning
- Source :
- Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]. 192(2)
- Publication Year :
- 2015
-
Abstract
- The potential of intensity-modulated radiation therapy (IMRT) as opposed to three-dimensional conformal radiotherapy (3D-CRT) is analyzed for two different concepts of fluorodeoxyglucose positron emission tomography (FDG PET)-based target volume delineation in locally advanced non-small cell lung cancer (LA-NSCLC): involved-field radiotherapy (IF-RT) vs. elective nodal irradiation (ENI). Treatment planning was performed for 41 patients with LA-NSCLC, using four different planning approaches (3D-CRT-IF, 3D-CRT-ENI, IMRT-IF, IMRT-ENI). ENI included a boost irradiation after 50 Gy. For each plan, maximum dose escalation was calculated based on prespecified normal tissue constraints. The maximum prescription dose (PD), tumor control probability (TCP), conformal indices (CI), and normal tissue complication probabilities (NTCP) were analyzed. IMRT resulted in statistically significant higher prescription doses for both target volume concepts as compared with 3D-CRT (ENI: 68.4 vs. 60.9 Gy, p
- Subjects :
- Lung Neoplasms
medicine.medical_treatment
Multimodal Imaging
030218 nuclear medicine & medical imaging
03 medical and health sciences
0302 clinical medicine
Imaging, Three-Dimensional
Fluorodeoxyglucose F18
Carcinoma, Non-Small-Cell Lung
medicine
Dosimetry
Radiology, Nuclear Medicine and imaging
Prospective Studies
Prospective cohort study
Radiation treatment planning
Neoplasm Staging
Fluorodeoxyglucose
Lymphatic Irradiation
medicine.diagnostic_test
Equivalent dose
business.industry
Radiotherapy Planning, Computer-Assisted
Radiation therapy
Oncology
Positron emission tomography
030220 oncology & carcinogenesis
Positron-Emission Tomography
Radiotherapy, Intensity-Modulated
Radiotherapy, Conformal
Nuclear medicine
business
Tomography, X-Ray Computed
Emission computed tomography
medicine.drug
Subjects
Details
- ISSN :
- 1439099X
- Volume :
- 192
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]
- Accession number :
- edsair.doi.dedup.....c87ec6549be107e7dbefbac7530edf83