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IL-6 is essential in TNF-alpha-induced fever
- Source :
- The American journal of physiology. 275(6)
- Publication Year :
- 1998
-
Abstract
- Tumor necrosis factor-alpha (TNF-alpha) is a pleiotropic cytokine that orchestrates an array of local and systemic effects. For instance, acute exposure to a high dose of TNF-alpha results in septic shock and fever. We have used interleukin-1beta (IL-1beta)- and interleukin-6 (IL-6)-deficient mice, along with their wild-type equivalents, to define a role for TNF-alpha in fever. Briefly, the mice produced prostaglandin E2-dependent fevers in response to recombinant murine TNF-alpha (rmTNF-alpha). Furthermore, rmTNF-alpha (12 microgram/mouse ip) triggered a febrile response in IL-1beta-deficient mice as well as in their corresponding wild-type controls. In contrast, the IL-6-deficient mice were resistant to rmTNF-alpha (4.5 microgram/mouse ip), although their wild-type counterparts readily mounted a fever. In the IL-6-deficient mice, moreover, the febrile response to rmTNF-alpha could be restored by a central administration of rat recombinant IL-6 (500 ng/mouse icv). We thus conclude that TNF-alpha can trigger fever independent of IL-1beta but dependent on IL-6. We also suggest that central, rather than peripheral, IL-6 (plasma IL-6 was measured 2 h after pyrogenic challenge) is essential in TNF-alpha-induced fever.
- Subjects :
- Male
Lipopolysaccharide
Fever
Physiology
Ratón
Microgram
medicine.medical_treatment
Prostaglandin
chemistry.chemical_compound
Mice
Reference Values
Physiology (medical)
medicine
Animals
Humans
Interleukin 6
Injections, Intraventricular
Mice, Knockout
biology
Septic shock
Interleukin-6
Tumor Necrosis Factor-alpha
medicine.disease
Recombinant Proteins
Rats
Cytokine
chemistry
Immunology
biology.protein
Tumor necrosis factor alpha
Injections, Intraperitoneal
Interleukin-1
Subjects
Details
- ISSN :
- 00029513
- Volume :
- 275
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- The American journal of physiology
- Accession number :
- edsair.doi.dedup.....c874f5df99fce39ff8da3ccbdfa2f48b