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Exploratory cohort study to determine if dry cow vaccination with a Salmonella Newport bacterin can protect dairy calves against oral Salmonella challenge
- Source :
- Journal of Veterinary Internal Medicine, Journal of Veterinary Internal Medicine, Vol 33, Iss 4, Pp 1796-1806 (2019)
- Publication Year :
- 2019
- Publisher :
- John Wiley & Sons, Inc., 2019.
-
Abstract
- Background Salmonellosis is a major cause of morbidity and mortality in neonatal calves, often occurring before preventative vaccines can be administered. Hypothesis/Objective To evaluate the protective effect on calves of colostrum from cows vaccinated with a commercially available Salmonella Newport bacterin against a Salmonella Typhimurium challenge. Animals Twenty Holstein bull calves from a university dairy farm. Methods Nonrandomized placebo‐controlled trial in which colostrum was harvested from 30 cows that received 2 doses of either Salmonella bacterin or saline before calving. Colostrum collected from each group was pooled and fed to 2 groups of 10 calves at birth. At approximately 2 weeks of age, calves were challenged with Salmonella Typhimurium. Clinical, hematologic, microbiological, and postmortem findings were compared between the 2 groups. Results No differences in mortality, clinical findings, hematology results, blood and fecal cultures, or necropsy findings between the 2 groups were observed. Vaccinated cows had higher colostral titers, and calves fed this colostrum had higher serum titers (mean difference, 0.429; mean [SE], 0.852 [0.02] for vaccinated versus 0.423 [0.02] for control calves). Conclusions and Clinical Importance Transfer of colostral immunoglobulins from Salmonella enterica serotype Newport bacterin to neonatal calves was not sufficient to decrease mortality, clinical signs, sepsis, intestinal damage, or fecal shedding when exposed to a highly pathogenic Salmonella isolate. A large‐scale randomized controlled clinical trial is needed to evaluate the efficacy of this bacterin when administered in the dry period for prevention of salmonellosis in neonatal calves.
- Subjects :
- Serotype
Male
Salmonella typhimurium
Salmonella
Veterinary medicine
Salmonella Vaccines
medicine.medical_treatment
animal diseases
Immunology
Ice calving
Cattle Diseases
Passive immunity
Standard Article
medicine.disease_cause
calves
Cohort Studies
medicine
Animals
Feces
FOOD AND FIBER ANIMAL
Salmonella Infections, Animal
lcsh:Veterinary medicine
General Veterinary
biology
business.industry
Colostrum
Vaccination
Salmonella enterica
biology.organism_classification
Standard Articles
passive immunity
Animals, Newborn
Bacterial Vaccines
lcsh:SF600-1100
Cattle
Female
business
Immunity, Maternally-Acquired
Subjects
Details
- Language :
- English
- ISSN :
- 19391676 and 08916640
- Volume :
- 33
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Journal of Veterinary Internal Medicine
- Accession number :
- edsair.doi.dedup.....c85c102d6f96377349d47f7d52df717f