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Quantitative Assessment of Intra-Patient Variation in CD4+ T Cell Counts in Stable, Virologically-Suppressed, HIV-Infected Subjects
- Source :
- PLoS ONE, PLoS ONE, Vol 10, Iss 6, p e0125248 (2015)
- Publication Year :
- 2015
- Publisher :
- Public Library of Science (PLoS), 2015.
-
Abstract
- Objectives Counts of absolute CD4+ T lymphocytes (CD4+ T cells) are known to be highly variable in untreated HIV-infected individuals, but there are no data in virologically-suppressed individuals. We investigated CD4+ T cell variability in stable, virologically-suppressed, HIV-1 infected adults on combination antiretroviral therapy (cART). Methods From a large hospital database we selected patients with stable virological suppression on cART for >3 years with >10 CD4+ T cell measurements performed over a further >2 years; and a control group of 95 patients not on cART. Results We identified 161 HIV-infected patients on cART without active HCV or HBV infection, with stable virological suppression for a median of 6.4 years. Over the study period 88 patients had reached a plateau in their absolute CD4+ T cell counts, while 65 patients had increasing and 8 patients had decreasing absolute CD4+ T cell counts. In patients with plateaued CD4+ T cell counts, variability in absolute CD4+ T cell counts was greater than in percent CD4+ T cells (median coefficient of variation (CV) 16.6% [IQR 13.8-20.1%] and CV 9.6% [IQR 7.4-13.0%], respectively). Patients with increasing CD4+ T cell counts had greater variability in absolute CD4+ T cell counts than those with plateaued CD4 T cell counts (CV 19.5% [IQR 16.1-23.8%], p
- Subjects :
- Adult
Male
Cart
medicine.medical_specialty
Coefficient of variation
T cell
lcsh:Medicine
HIV Infections
CD8-Positive T-Lymphocytes
Gastroenterology
Antiretroviral Therapy, Highly Active
Internal medicine
medicine
Humans
Clinical significance
lcsh:Science
Retrospective Studies
Multidisciplinary
Cd4 t cell
business.industry
lcsh:R
Middle Aged
Antiretroviral therapy
CD4 Lymphocyte Count
Treatment Outcome
medicine.anatomical_structure
Immunology
Cohort
lcsh:Q
Female
business
Viral load
Research Article
Subjects
Details
- ISSN :
- 19326203
- Volume :
- 10
- Database :
- OpenAIRE
- Journal :
- PLOS ONE
- Accession number :
- edsair.doi.dedup.....c85266566d08581dd3ecb43f03927e9f