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Influence of proband's characteristics on the risk for venous thromboembolism in relatives with factor V Leiden or prothrombin G20210A polymorphisms
- Publication Year :
- 2013
-
Abstract
- In family studies, the risk for venous thromboembolism (VTE) in relatives with factor V Leiden (FVL) or G20210A prothrombin (PT20210A) gene polymorphisms may differ according to genotype and clinical presentation of the proband. To address this hypothesis, a retrospective cohort family study was carried out on 192 kindreds with at least one member with homozygous FVL or PT20210A, for a total of 886 relatives. The proband of the family was heterozygous in 68 and homozygous or with both polymorphisms in 124 kindreds. Twenty-three probands were asymptomatic, 11 had had arterial thrombosis, 7 obstetrical complications, and 151 venous thrombosis (122 VTE and 29 superficial vein thrombosis). The incidence of VTE (per 1000 patient-years) in relatives was higher when the proband had heterozygous rather than homozygous polymorphism (1.25 [95\% confidence interval (CI), 0.73-1.91] vs 0.44 [0.19-0.78]) and when the proband had had VTE instead of other or no clinical manifestations (0.95 [0.57-1.42] vs 0.50 [0.19-0.96]). Compared with relatives belonging to kindreds with homozygous probands without VTE, the adjusted hazard ratio of VTE for relatives selected from kindreds with heterozygous probands with VTE was 4.14 (95\% CI, 1.17-14.71). The genotype and clinical presentation of the proband influence the risk for VTE in relatives with FVL or PT20210A.
- Subjects :
- Adult
Male
Proband
medicine.medical_specialty
Genotype
Superficial vein thrombosis
Immunology
Adult, Disease-Free Survival, Factor V
Biochemistry
Disease-Free Survival
Genetic
Risk Factors
Internal medicine
Factor V Leiden
Humans
Medicine
Genetic Predisposition to Disease
Superficial thrombophlebitis
cardiovascular diseases
Polymorphism
genetics, Risk Factors, Venous Thromboembolism
Polymorphism, Genetic
biology
business.industry
Factor V
Retrospective cohort study
Venous Thromboembolism
Cell Biology
Hematology
Middle Aged
medicine.disease
equipment and supplies
Surgery
epidemiology/genetics, Genotype, Humans, Male, Middle Aged, Polymorphism
genetics, Female, Genetic Predisposition to Disease
blood/epidemiology/genetics
Settore MED/15 - MALATTIE DEL SANGUE
Venous thrombosis
genetics, Prothrombin
biology.protein
Prothrombin G20210A
Female
Prothrombin
business
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....c84546242a5e1ca25d5d58eac619097f