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Aqueous Dissolution of Alzheimer's Disease Aβ Amyloid Deposits by Biometal Depletion
- Source :
- Journal of Biological Chemistry. 274:23223-23228
- Publication Year :
- 1999
- Publisher :
- Elsevier BV, 1999.
-
Abstract
- Zn(II) and Cu(II) precipitate Abeta in vitro into insoluble aggregates that are dissolved by metal chelators. We now report evidence that these biometals also mediate the deposition of Abeta amyloid in Alzheimer's disease, since the solubilization of Abeta from post-mortem brain tissue was significantly increased by the presence of chelators, EGTA, N,N,N',N'-tetrakis(2-pyridyl-methyl) ethylene diamine, and bathocuproine. Efficient extraction of Abeta also required Mg(II) and Ca(II). The chelators were more effective in extracting Abeta from Alzheimer's disease brain tissue than age-matched controls, suggesting that metal ions differentiate the chemical architecture of amyloid in Alzheimer's disease. Agents that specifically chelate copper and zinc ions but preserve Mg(II) and Ca(II) may be of therapeutic value in Alzheimer's disease.
- Subjects :
- Amyloid
Metal ions in aqueous solution
chemistry.chemical_element
Biochemistry
chemistry.chemical_compound
Alzheimer Disease
mental disorders
Humans
Chelation
Egtazic Acid
Molecular Biology
Chelating Agents
Amyloid beta-Peptides
Aqueous solution
Chemistry
Brain
Water
Cell Biology
Ethylenediamines
Copper
In vitro
Zinc
EGTA
PBT2
Phenanthrolines
Subjects
Details
- ISSN :
- 00219258
- Volume :
- 274
- Database :
- OpenAIRE
- Journal :
- Journal of Biological Chemistry
- Accession number :
- edsair.doi.dedup.....c8415608e00ddafd60ed030b6c683a3e