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Self-referential processing during observation of a speech performance task in social anxiety disorder from pre- to post-treatment: Evidence of disrupted neural activation
- Publication Year :
- 2019
- Publisher :
- eScholarship, University of California, 2019.
-
Abstract
- Self-referential processing is critical to understanding social anxiety disorder (SAD). This study examined neural differences in self-referential processing in healthy controls (HC) and participants with SAD at pre- and post-treatment. Participants (n = 64) underwent fMRI scanning while viewing a video of themselves (“Self”) or another person (“Other”). SAD participants were randomized to cognitive behavior therapy (CBT), acceptance and commitment therapy (ACT), or waitlist, and were re-scanned at post-treatment. In SAD vs. HC, the fusiform face area (FFA) showed significantly more activation during Self vs. Other, and greater SAD severity was associated with significantly more activation during Self vs. Other in the right FFA and the left extrastriate body area (EBA). Greater reduction in SAD severity was associated with stronger connectivity between the amygdala and FFA during Self vs. Other at post-treatment, whereas the strength of connectivity during Self and Other was comparable at post-treatment for those with less SAD reduction. Thus, there were significant differences in activation and functional connectivity of brain regions implicated in self-referential processing in SAD. Change in connectivity between the amygdala and FFA were observed as a function of change in SAD severity, suggesting that improvements in SAD severity may correct this altered functional connectivity.
- Subjects :
- Male
Self-Assessment
6.6 Psychological and behavioural
Phobia
Audiology
Acceptance and commitment therapy
0302 clinical medicine
Social anxiety disorder
Psychiatry
Functional connectivity
Social anxiety
Brain
Cognition
Amygdala
Magnetic Resonance Imaging
Psychiatry and Mental health
medicine.anatomical_structure
Treatment Outcome
Mental Health
Cognitive behavior therapy
behavior and behavior mechanisms
Female
Cognitive Sciences
Psychology
psychological phenomena and processes
Self-referential processing
Adult
medicine.medical_specialty
1.1 Normal biological development and functioning
Clinical Sciences
Neuroscience (miscellaneous)
behavioral disciplines and activities
Article
Extrastriate body area
03 medical and health sciences
Young Adult
Social
Clinical Research
Underpinning research
mental disorders
Behavioral and Social Science
medicine
Humans
Speech
Radiology, Nuclear Medicine and imaging
Acceptance and Commitment Therapy
Cognitive Behavioral Therapy
Neurosciences
Evaluation of treatments and therapeutic interventions
Phobia, Social
Fusiform face area
030227 psychiatry
Post treatment
030217 neurology & neurosurgery
Subjects
Details
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....c83f051a609624ccfe92d6a42c2e0c1f