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Bronchial Epithelial Calcium Metabolism Impairment in Smokers and Chronic Obstructive Pulmonary Disease Decreased ORAI3 Signaling
- Source :
- American Journal of Respiratory Cell and Molecular Biology, American Journal of Respiratory Cell and Molecular Biology, 2019, 61 (4), pp.501-511. ⟨10.1165/rcmb.2018-0228OC⟩, American Journal of Respiratory Cell and Molecular Biology, American Thoracic Society, 2019, 61 (4), pp.501-511. ⟨10.1165/rcmb.2018-0228OC⟩
- Publication Year :
- 2019
- Publisher :
- HAL CCSD, 2019.
-
Abstract
- The airway epithelium represents a fragile environmental interface potentially disturbed by cigarette smoke (CS), the major risk factor for developing chronic obstructive pulmonary disease (COPD). CS leads to bronchial epithelial damage on ciliated, goblet, and club cells, which could involve calcium (Ca
- Subjects :
- 0301 basic medicine
Male
[SDV]Life Sciences [q-bio]
Clinical Biochemistry
Mucin 5AC
Endoplasmic Reticulum
Pulmonary Disease, Chronic Obstructive
0302 clinical medicine
Smoke
Cigarette smoke
Medicine
Cells, Cultured
bronchial epithelial cells
Calcium signaling
COPD
Smokers
cigarette smoke
Smoking
Middle Aged
3. Good health
ORAI3
Benzamides
Cytokines
Female
Signal Transduction
Pulmonary and Respiratory Medicine
Adult
Pulmonary disease
Bronchi
Respiratory Mucosa
calcium signaling
03 medical and health sciences
Humans
Cilia
Risk factor
Molecular Biology
Aged
Calcium metabolism
business.industry
Interleukin-8
Epithelial Cells
Cell Biology
medicine.disease
respiratory tract diseases
Mucus
030104 developmental biology
030228 respiratory system
Gene Expression Regulation
Immunology
Respiratory epithelium
Pyrazoles
Calcium
Calcium Channels
business
Subjects
Details
- Language :
- English
- ISSN :
- 10441549 and 15354989
- Database :
- OpenAIRE
- Journal :
- American Journal of Respiratory Cell and Molecular Biology, American Journal of Respiratory Cell and Molecular Biology, 2019, 61 (4), pp.501-511. ⟨10.1165/rcmb.2018-0228OC⟩, American Journal of Respiratory Cell and Molecular Biology, American Thoracic Society, 2019, 61 (4), pp.501-511. ⟨10.1165/rcmb.2018-0228OC⟩
- Accession number :
- edsair.doi.dedup.....c837df80280227e803d23693e32f209d