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The effects of chlormequat chloride on the development of pubertal male rats
- Source :
- Environmental Toxicology and Pharmacology. 47:92-99
- Publication Year :
- 2016
- Publisher :
- Elsevier BV, 2016.
-
Abstract
- Chlormequat Chloride (CCC) is a plant growth regulator that is widely applied in agriculture. Previous studies have shown that long-term exposure of CCC could decrease body weight in animals. However, the underlying mechanisms have not been studied. In this study, CCC was administered to rats daily by gavage on postnatal days 23-60 at doses of 0, 75, 150 and 300mg/kg bw/d. The results showed that body weight and the length of the right femur were significantly decreased in the 300mg/kg bw/d group. Histological analysis of proximal growth plates of the right femurs showed narrowed proliferative zones and hypertrophic zones in CCC-treated groups. The mRNA expression of growth hormone, growth hormone receptor and insulin like growth factor 1 were decreased in the CCC-treated group. The results indicated that CCC may affect the expression of growth hormone and insulin-like growth factor 1 and subsequently cause a decrease in body weight and bone length.
- Subjects :
- Male
0301 basic medicine
medicine.medical_specialty
Chlormequat
Health, Toxicology and Mutagenesis
medicine.medical_treatment
Developmental toxicity
030209 endocrinology & metabolism
Growth hormone receptor
Toxicology
Growth hormone
Chloride
Rats, Sprague-Dawley
03 medical and health sciences
chemistry.chemical_compound
Insulin-like growth factor
0302 clinical medicine
Plant Growth Regulators
Internal medicine
Male rats
medicine
Animals
Growth Plate
Insulin-Like Growth Factor I
Pharmacology
Chemistry
Growth factor
Body Weight
Puberty
Organ Size
Receptors, Somatotropin
General Medicine
Acetylcholine
030104 developmental biology
Endocrinology
Gene Expression Regulation
Growth Hormone
medicine.drug
Subjects
Details
- ISSN :
- 13826689
- Volume :
- 47
- Database :
- OpenAIRE
- Journal :
- Environmental Toxicology and Pharmacology
- Accession number :
- edsair.doi.dedup.....c832a1f3993d3577341eab388637d977