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Continuous hemodiafiltration with polymyxin-B immobilized fiber is effective in patients with sepsis syndrome and acute renal failure
- Source :
- Therapeutic apheresis : official journal of the International Society for Apheresis and the Japanese Society for Apheresis. 6(3)
- Publication Year :
- 2002
-
Abstract
- The aim of this study was first, to evaluate the effects of continuous hemodiafiltration (CHDF) alone or combined with CHDF and polymyxin-B immobilized fiber (PMX) on survival rates of patients with sepsis and acute renal failure, and second, to evaluate the changes in plasma levels of inflammatory cytokines before and after treatment with CHDF and PMX and CHDF alone in these patients. Forty-eight patients with septic shock and acute renal failure were enrolled in this study. The survival rate of all patients at 28 days was 25% for those with CHDF and 75% for those with PMX and CHDF treatment. Combination treatment produced a significant reduction of plasma levels of endotoxin and interleukin-6 compared to the basal values and to the treatment with CHDF alone. From these data, it is suggested that the combined therapy with PMX and CHDF is effective in improvement of survival rate of patients with septic shock and acute renal failure.
- Subjects :
- Male
medicine.medical_specialty
Urology
Hemodiafiltration
Proinflammatory cytokine
Sepsis
Continuous hemodiafiltration
medicine
Humans
In patient
Intensive care medicine
Survival rate
Aged
Polymyxin B
APACHE II
business.industry
Septic shock
Hematology
Acute Kidney Injury
Middle Aged
medicine.disease
Systemic Inflammatory Response Syndrome
Endotoxins
Survival Rate
Nephrology
Female
business
medicine.drug
Subjects
Details
- ISSN :
- 10916660
- Volume :
- 6
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Therapeutic apheresis : official journal of the International Society for Apheresis and the Japanese Society for Apheresis
- Accession number :
- edsair.doi.dedup.....c8237acd0fcfa6c4cd96dea058c7dd09