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Development of an LC-MS method for determination of nitrogen-containing heterocycles using mixed-mode liquid chromatography
- Source :
- Analytical and Bioanalytical Chemistry
- Publication Year :
- 2022
- Publisher :
- Springer, 2022.
-
Abstract
- N-containing heterocycles (NCHs) are largely used as precursors for pharmaceuticals and can enter the environment. Some NCHs have been shown to be toxic, persistent, and very mobile in the environment. Thus, they have received increasing attention in the past years. However, the analysis of these polar compounds in environmental samples is still a challenge for liquid chromatography. This paper investigates the use of mixed-mode liquid chromatography (MMLC), which has reversed-phase and ion exchange characteristics for measurements of NCHs in water. NCHs with low pKa (i.e., Ka (i.e., > 5) interact by a mixture of reversed-phase/ion exchange/HILIC mechanism. It was also shown that the presented method performs well in the quantification of the majority of the selected NCHs in surface water with MDLs between 3 and 6 μg/L, a low matrix effect and recoveries in the range of 77–96% except for pyridazine exhibiting 32% were achieved. The method was successfully employed to follow the degradation of NCHs in ozonation.
- Subjects :
- Nitrogen-containing heterocycles
Chromatography
Ion exchange
Hydrophilic interaction chromatography
010401 analytical chemistry
Chemie
Liquid chromatography
chemistry.chemical_element
Cation exchange
010501 environmental sciences
Mixed mode
01 natural sciences
Biochemistry
Nitrogen
0104 chemical sciences
Analytical Chemistry
Pyridazine
Mixed-mode chromatography
chemistry.chemical_compound
Reversed-phase
chemistry
Liquid chromatography–mass spectrometry
0105 earth and related environmental sciences
Research Paper
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Analytical and Bioanalytical Chemistry
- Accession number :
- edsair.doi.dedup.....c81a3c26b4b78efdd0d1180b7b5fb4f5