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The transcription factor E2F1 controls the GLP-1 receptor pathway in pancreatic β cells
- Source :
- Cell Reports, Cell Reports, 2022, 40 (6), pp.111170. ⟨10.1016/j.celrep.2022.111170⟩
- Publication Year :
- 2021
-
Abstract
- The glucagon-like peptide 1 (Glp-1) has emerged as a hormone with broad pharmacological potential in type 2 diabetes (T2D) treatment, notably by improving β cell functions. The cell-cycle regulator and transcription factor E2f1 is involved in glucose homeostasis by modulating β cell mass and function. Here, we report that β cell-specific genetic ablation of E2f1 (E2f1
- Subjects :
- Glucose
Diabetes Mellitus, Type 2
[SDV]Life Sciences [q-bio]
Insulin-Secreting Cells
Exenatide
Humans
Insulin
[SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology
General Biochemistry, Genetics and Molecular Biology
E2F1 Transcription Factor
Glucagon-Like Peptide-1 Receptor
Subjects
Details
- ISSN :
- 22111247
- Volume :
- 40
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Cell reports
- Accession number :
- edsair.doi.dedup.....c8059f1ee5af23e05214ce25a0741573
- Full Text :
- https://doi.org/10.1016/j.celrep.2022.111170⟩