Autologous stem cells transplantation in the first remission of follicular lymphoma as 'rescue therapy' in patients with unfavorable prognosis factors. The first prospective study results

Authors :: S K Kravchenko
E A Baryakh
Eduard G. Gemdzhian
N G Chernova
Ya K Mangasarova
V G Savchenko
V I Vorob'ev
A E Misyurina
E S Nesterova
Source :: Современная онкология, Vol 18, Iss 5, Pp 31-32 (2016)
Publication Year :: 2016
Publisher :: LLC Obyedinennaya Redaktsiya, 2016.
Abstract: The purpose of the study was to evaluate high-dose chemotherapy efficacy with the next autologous stem cells transplantation (ASCT) in first-line treatment of follicular lymphoma (FL) patients with unfavorable prognosis factors. 43 FL patients with unfavorable prognosis factors were observed in Hematological scientific center from 2000 to 2016. The patients received R-CHOP regime as induction therapy. ASCT in first-line treatment after inductional R-CHOP regimes was administrated in 23 patients. The results of the first prospective study of high-dose therapy in FL patients in Russia demonstrate that HDCT with followed ASCT in first line therapy allows to achieve complete remission in patients with unfavorable prognosis factors as well as to increase progression-free survival and overall surviva.

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