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Gray matter network disruptions and amyloid beta in cognitively normal adults

Authors :: Jorge Villanua
Maite Garcia Sebastian
Philip Scheltens
Ainara Estanga
Andrea Izagirre
Pablo Martinez Lage
Montserrat Clerigue
Wiesje M. van der Flier
Frederik Barkhof
Betty M. Tijms
Pieter Jelle Visser
Mara ten Kate
Mirian Ecay
Ernesto Sanz Arigita
Alle Meije Wink
Neurology
Amsterdam Neuroscience - Neurodegeneration
Radiology and nuclear medicine
Epidemiology and Data Science
RS: MHeNs - R1 - Cognitive Neuropsychiatry and Clinical Neuroscience
Psychiatrie & Neuropsychologie
Source :: Tijms, B M, ten Kate, M, Wink, A M, Visser, P J, Ecay, M, Clerigue, M, Estanga, A, Garcia Sebastian, M, Izagirre, A, Villanua, J, Martinez Lage, P, van der Flier, W M, Scheltens, P, Sanz Arigita, E & Barkhof, F 2016, ' Gray matter network disruptions and amyloid beta in cognitively normal adults ', Neurobiology of Aging, vol. 37, pp. 154-160 . https://doi.org/10.1016/j.neurobiolaging.2015.10.015, Neurobiology of Aging, 37, 154-160. Elsevier Inc., Neurobiology of Aging, 37, 154-160. Elsevier Science
Publication Year :: 2016
Abstract: Gray matter networks are disrupted in Alzheimer's disease (AD). It is unclear when these disruptions start during the development of AD. Amyloid beta 1-42 (A beta(42)) is among the earliest changes in AD. We studied, in cognitively healthy adults, the relationship between A beta(42) levels in cerebrospinal fluid (CSF) and single-subject cortical gray matter network measures. Single-subject gray matter networks were extracted from structural magnetic resonance imaging scans in a sample of cognitively healthy adults (N = 185; age range 39-79, mini-mental state examination >25, N = 12 showed abnormal A beta(42)