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Actin assembly states in Dictyostelium discoideum at different stages of development and during cellular stress
- Source :
- The International Journal of Developmental Biology. 63:417-427
- Publication Year :
- 2019
- Publisher :
- UPV/EHU Press, 2019.
-
Abstract
- The actin cytoskeleton of non-muscle cells is essential for cellular structure and subcellular organization, and the dynamic regulation of actin assembly and disassembly is a prerequisite for motility. Pioneering work using Dictyostelium discoideum focused on the biochemical analysis of non-muscle actin, the identification of actin-regulating proteins and their specific functions during processes like cell migration, cytokinesis, phagocytosis, and morphogenesis. Although subsequent work in higher eukaryotes revealed that the processes regulating actin dynamics are often much more complex, results obtained by using Dictyostelium have been of fundamental importance because they have contributed significantly to our understanding of the actin cytoskeleton in higher eukaryotes. Dictyostelium is an accepted model system for studying fast moving cells, because the single cells of the organism share many similarities with cells of the immune system such as human neutrophils. Here we provide a brief overview on the milestones of research of the actin cytoskeleton taking advantage of Dictyostelium. Furthermore, we summarize how actin structures and cytoskeletal dynamics at different stages of development have been visualized, and give an overview on the current focus of research. In addition, we discuss results showing actin assembly states during phases of cellular stress and how stress-induced actin assembly states may contribute to our understanding of certain diseases.
- Subjects :
- Embryology
Neutrophils
Morphogenesis
macromolecular substances
Models, Biological
Dictyostelium discoideum
03 medical and health sciences
Phagocytosis
Cell Movement
Humans
Dictyostelium
Cytoskeleton
Actin
Cytokinesis
030304 developmental biology
Cell Nucleus
Photons
0303 health sciences
biology
Cell migration
Actin cytoskeleton
biology.organism_classification
Actins
Cell biology
Actin Cytoskeleton
Developmental Biology
Subjects
Details
- ISSN :
- 02146282
- Volume :
- 63
- Database :
- OpenAIRE
- Journal :
- The International Journal of Developmental Biology
- Accession number :
- edsair.doi.dedup.....c7f7f52145c2c7606ca5740e4954df4d