Back to Search
Start Over
Vitamin D receptor gene polymorphisms in atopy
- Source :
- Immunity, Inflammation and Disease, Immunity, Inflammation and Disease, Vol 9, Iss 4, Pp 1153-1159 (2021)
- Publication Year :
- 2021
- Publisher :
- Wiley, 2021.
-
Abstract
- Background The occurrence of allergic conditions, for example allergic asthma, rhinitis, and atopic dermatitis, is rising worldwide. These allergic conditions are associated with poor life quality. Vitamin D is proposed to be linked with increased risk and severe forms of allergic diseases. Aims This review article aimed to evaluate the vitamin D level role and polymorphisms of vitamin D receptor gene (VDR) in atopy. Methods & Materials We analyzed publications that were focusing on levels of vitamin D and/or polymorphism analysis of vitamin D receptor gene in allergic asthma, rhinitis, and atopic dermatitis patients. Results We noticed that levels of vitamin D are extensively studied in atopy by many research groups, however, polymorphisms of vitamin D receptor gene and their link with levels of vitamin D lack comprehensive data. There is evidence that vitamin D may be associated with anti‐inflammatory effects in allergic diseases. Some of VDR polymorphisms also may play a role in pathogenesis of these diseases. However, the data from different studies are controversial. Discussion The results of different studies are usually inconsistent, most probably due to populational bias or differences in methodology. Even though, more evidence shows a positive impact of vitamin D on the risk and outcomes of allergic diseases, especially atopic dermatitis, and asthma. Conclusions There is controversial data about the level of vitamin D and its role in atopy; however, more evidence shows a positive impact on the risk and outcomes of allergic diseases.<br />Some evidence suggests that vitamin D is linked with increased risk and more severe forms of allergic diseases. Therefore, this review article aimed to evaluate the role of vitamin D level and vitamin D receptor gene (VDR) polymorphisms in atopy. We found that vitamin D levels in atopy are extensively studied by many research groups, however, vitamin D receptor gene polymorphisms and their link with vitamin D levels lack comprehensive data. Even though, more evidence shows a positive impact on the risk and outcomes of allergic diseases, especially atopic dermatitis and asthma.
- Subjects :
- Immunology
atopy
vitamin D
Review Article
Calcitriol receptor
Dermatitis, Atopic
Pathogenesis
Atopy
Hypersensitivity
Vitamin D and neurology
medicine
Humans
Immunology and Allergy
Review Articles
VDR
Asthma
Polymorphism, Genetic
business.industry
Atopic dermatitis
RC581-607
medicine.disease
Review article
Receptors, Calcitriol
Immunologic diseases. Allergy
Vitamin d receptor gene
business
Subjects
Details
- ISSN :
- 20504527
- Volume :
- 9
- Database :
- OpenAIRE
- Journal :
- Immunity, Inflammation and Disease
- Accession number :
- edsair.doi.dedup.....c7f6a829e818e31b3e5b2c25016a79d9