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Transcatheter Versus Surgical Closure of Perimembranous Ventricular Septal Defects in Children
- Source :
- Journal of the American College of Cardiology. 63(12):1159-1168
- Publication Year :
- 2014
- Publisher :
- Elsevier BV, 2014.
-
Abstract
- Objectives The objective of this study was to evaluate the safety and efficacy of the surgical versus transcatheter approach to correct perimembranous ventricular septal defects (pmVSDs) in a prospective, randomized, controlled clinical trial. Background pmVSD is a common congenital heart disease in children. Surgical closure of pmVSD is a well-established therapy but requires open-heart surgery with cardiopulmonary bypass. Although the transcatheter approach is associated with significant incidence of complete atrioventricular block, it may provide a less invasive alternative. Critical comparison of the safety and efficacy of the 2 interventions necessitates a prospective, randomized, controlled trial. Methods Between January 2009 and July 2010, 229 children with pmVSD were randomly assigned to surgical or transcatheter intervention. Clinical, laboratory, procedural, and follow-up data over a 2-year period were compared. Results Neither group had mortality or major complications. However, statistical analysis of the 2 groups demonstrated significant differences (p Conclusions Transcatheter device closure and surgical repair are effective interventions with excellent midterm results for treating pmVSD in children. Transcatheter device closure has a lower incidence of myocardial injury, less blood transfused, faster recovery, shorter hospital stay, and lower medical expenses. (Transcatheter Closure Versus Surgery of Perimembranous Ventricular Septal Defects; NCT00890799 )
- Subjects :
- Surgical repair
medicine.medical_specialty
Heart disease
business.industry
Incidence (epidemiology)
medicine.disease
Surgery
law.invention
Clinical trial
Randomized controlled trial
law
medicine
Cardiopulmonary bypass
Closure (psychology)
business
Cardiology and Cardiovascular Medicine
Atrioventricular block
Subjects
Details
- ISSN :
- 07351097
- Volume :
- 63
- Issue :
- 12
- Database :
- OpenAIRE
- Journal :
- Journal of the American College of Cardiology
- Accession number :
- edsair.doi.dedup.....c7f37329794d1e98001c511315a9f450
- Full Text :
- https://doi.org/10.1016/j.jacc.2014.01.008