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Lymphocyte subsets and natural killer cell cytotoxicity after laparoscopically assisted resection of rectosigmoid carcinoma
- Source :
- Surgical Endoscopy. 17:1305-1310
- Publication Year :
- 2003
- Publisher :
- Springer Science and Business Media LLC, 2003.
-
Abstract
- Background: Laparoscopically assisted resection of colorectal carcinoma is technically feasible and minimally invasive. Postoperative immunosuppression also may be reduced. This study compared the lymphocyte subsets and natural killer (NK) cell cytotoxicity in patients after laparoscopically assisted resection with those after open resection of rectosigmoid carcinoma. Methods: In this study, 40 patients with rectosigmoid carcinoma, but no evidence of metastasis, were randomized to receive either laparoscopically assisted or conventional open resection of the tumor. Blood was collected before the operation, then 24 h, 72 h, and 8 days after the operation for studies of lymphocyte subsets and NK cell cytotoxicity. Results: The lymphocyte subsets and NK cell cytotoxicity of both groups showed typical suppression after surgery. The suppression of T cell activation and NK-like T cells was significantly less after laparoscopically assisted resection than in after open resection, whereas the difference in other lymphocyte subsets and NK cell cytotoxicity was not significant. Conclusion: This study showed that some cellular components of the immune system are less suppressed after laparoscopically assisted than after conventional open resection of rectosigmoid carcinoma. This may have implications for tumor recurrence and long-term patient survival.
- Subjects :
- Cytotoxicity, Immunologic
Male
Pathology
medicine.medical_specialty
Colorectal cancer
T cell
medicine.medical_treatment
Urology
Comorbidity
Immunophenotyping
Natural killer cell
Metastasis
Lymphopenia
Open Resection
medicine
Humans
Cytotoxic T cell
Lymphocyte Count
Postoperative Period
Prospective Studies
Rectosigmoid Carcinoma
Aged
Aged, 80 and over
Immunosuppression Therapy
Immunity, Cellular
Laparotomy
Rectal Neoplasms
business.industry
Carcinoma
Immunosuppression
Middle Aged
medicine.disease
Lymphocyte Subsets
Killer Cells, Natural
Sigmoid Neoplasms
medicine.anatomical_structure
Female
Laparoscopy
Surgery
business
Subjects
Details
- ISSN :
- 14322218 and 09302794
- Volume :
- 17
- Database :
- OpenAIRE
- Journal :
- Surgical Endoscopy
- Accession number :
- edsair.doi.dedup.....c7e6152ceb262ea8b8ebd05054da5182