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Surface-Functionalized Biodegradable Nanoparticles Consisting of Amphiphilic Graft Polymers Prepared by Radical Copolymerization of 2-Methylene-1,3-Dioxepane and Macromonomers
- Source :
- Langmuir : the ACS journal of surfaces and colloids. 31(24)
- Publication Year :
- 2015
-
Abstract
- Biodegradable polyester-based nanoparticles were prepared by the precipitation of amphiphilic graft copolymers, which were prepared by the ring-opening radical copolymerization of 2-methylene-1,3-dioxepane (MDO) and amphiphilic macromonomers. The diameter of the nanoparticles was controlled by the degree of grafting and the molecular weight of the grafting oligomer. PMDO-g-poly(ethylene glycol) nanoparticles were degraded by the alkaline hydrolysis of the polyester backbone. Although the colloidal stability of nanoparticles was retained due to the reorientation of the PEG chains during hydrolysis, the size of the nanoparticles decreased with increasing hydrolysis time. We also prepared PMDO-g-poly(N-isopropylacrylamide) nanoparticles, which show aggregation in response to increasing temperature.
- Subjects :
- Free Radicals
Polymers
Surface Properties
Nanoparticle
chemistry.chemical_compound
Surface-Active Agents
Polymer chemistry
Amphiphile
Electrochemistry
Copolymer
General Materials Science
Alkaline hydrolysis
Spectroscopy
chemistry.chemical_classification
Molecular Structure
Hydrolysis
Surfaces and Interfaces
Polymer
Condensed Matter Physics
Grafting
Polyester
chemistry
Cyclization
Oxepins
Nanoparticles
Ethylene glycol
Subjects
Details
- ISSN :
- 15205827
- Volume :
- 31
- Issue :
- 24
- Database :
- OpenAIRE
- Journal :
- Langmuir : the ACS journal of surfaces and colloids
- Accession number :
- edsair.doi.dedup.....c7e0ddf1b606ea0518d643de74c896f9