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Non-Alcoholic Fatty Liver Disease in Patients with Type 2 Diabetes Mellitus: A Position Statement of the Fatty Liver Research Group of the Korean Diabetes Association
- Source :
- Diabetes & Metabolism Journal, Vol 44, Iss 3, Pp 382-401 (2020), Diabetes & Metabolism Journal
- Publication Year :
- 2020
- Publisher :
- Korean Diabetes Association, 2020.
-
Abstract
- This clinical practice position statement, a product of the Fatty Liver Research Group of the Korean Diabetes Association, proposes recommendations for the diagnosis, progression and/or severity assessment, management, and follow-up of non-alcoholic fatty liver disease (NAFLD) in patients with type 2 diabetes mellitus (T2DM). Patients with both T2DM and NAFLD have an increased risk of non-alcoholic steatohepatitis (NASH) and fibrosis and a higher risk of cardiovascular diseases and diabetic complications compared to those without NAFLD. With regards to the evaluation of patients with T2DM and NAFLD, ultrasonography-based stepwise approaches using noninvasive biomarker models such as fibrosis-4 or the NAFLD fibrosis score as well as imaging studies such as vibration-controlled transient elastography with controlled attenuation parameter or magnetic resonance imaging-proton density fat fraction are recommended. After the diagnosis of NAFLD, the stage of fibrosis needs to be assessed appropriately. For management, weight reduction achieved by lifestyle modification has proven beneficial and is recommended in combination with antidiabetic agent(s). Evidence that some antidiabetic agents improve NAFLD/NASH with fibrosis in patients with T2DM is emerging. However, there are currently no definite pharmacologic treatments for NAFLD in patients with T2DM. For specific cases, bariatric surgery may be an option if indicated.
- Subjects :
- medicine.medical_specialty
Endocrinology, Diabetes and Metabolism
Bariatric Surgery
030209 endocrinology & metabolism
Disease
Review
Comorbidity
030204 cardiovascular system & hematology
Gastroenterology
digestive system
lcsh:Diseases of the endocrine glands. Clinical endocrinology
Diabetes Complications
03 medical and health sciences
0302 clinical medicine
Weight loss
Fibrosis
Risk Factors
cardiovascular disease
Internal medicine
Diabetes mellitus
Republic of Korea
medicine
Prevalence
Humans
Hypoglycemic Agents
Guideline/Fact Sheet
lcsh:RC648-665
business.industry
Fatty liver
Type 2 Diabetes Mellitus
nutritional and metabolic diseases
non-alcoholic fatty liver disease
life style
medicine.disease
digestive system diseases
Treatment Outcome
Liver
diabetes mellitus, type 2
Cardiovascular Diseases
Steatohepatitis
medicine.symptom
Transient elastography
business
Subjects
Details
- Language :
- English
- ISSN :
- 22336087 and 22336079
- Volume :
- 44
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Diabetes & Metabolism Journal
- Accession number :
- edsair.doi.dedup.....c7db4af66edf50e0f55c9a4b6a65b2a2