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Potential Prognostic Role of 18F-FDG PET/CT in Invasive Epithelial Ovarian Cancer Relapse. A Preliminary Study
- Source :
- Cancers, Vol 11, Iss 5, p 713 (2019), Cancers, Volume 11, Issue 5
- Publication Year :
- 2019
- Publisher :
- MDPI AG, 2019.
-
Abstract
- Epithelial ovarian cancer (EOC) is the most lethal gynecological malignancy, with relapse occurring in about 70% of advanced cases with poor prognosis. Fluorine-18-2-fluoro-2-deoxy-d-glucose PET/CT (18F-FDGPET/CT) is the most specific radiological imaging used to assess recurrence. Some intensity-based and volume-based PET parameters, maximum standardized uptake values (SUVmax), metabolic tumor volume (MTV) and total lesion glycolysis (TLG), are indicated to have a correlation with treatment response. The aim of our study is to correlate these parameters with post relapse survival (PRS) and overall survival (OS) in Epithelial Ovarian Cancer (EOC) relapse. The study included 50 patients affected by EOC relapse who underwent 18F-FDGPET/CT before surgery. All imaging was reviewed and SUVmax, MTV and TLG were calculated and correlated to PRS and OS. PRS and OS were obtained from the first relapse and from the first diagnosis to the last follow up or death, respectively. SUVmax, MTV and TLG were tested in a univariate logistic regression analysis, only SUVmax demonstrated to be significantly associated to PRS and OS (p = 0.005 and p = 0.024 respectively). Multivariate analysis confirmed the results. We found a cut-off of SUVmax of 13 that defined worse or better survival (p = 0.003). In the first relapse of EOC, SUVmax is correlated to PRS and OS, and when SUVmax is greater than 13, it is an unfavorable prognostic factor.
- Subjects :
- 0301 basic medicine
Oncology
Cancer Research
medicine.medical_specialty
Multivariate analysis
PET/CT
medicine.medical_treatment
Logistic regression
lcsh:RC254-282
Targeted therapy
03 medical and health sciences
0302 clinical medicine
Internal medicine
medicine
Epithelial ovarian cancer
relapse
PET-CT
business.industry
SUVmax
Metabolic tumor volume
medicine.disease
targeted therapy
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
030104 developmental biology
ovarian cancer
030220 oncology & carcinogenesis
Fdg pet ct
prognosis
Ovarian cancer
business
Subjects
Details
- Language :
- English
- ISSN :
- 20726694
- Volume :
- 11
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Cancers
- Accession number :
- edsair.doi.dedup.....c7ced523180fd137037918e487fcfded