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Potential Prognostic Role of 18F-FDG PET/CT in Invasive Epithelial Ovarian Cancer Relapse. A Preliminary Study

Authors :
Stefano Fanti
Sara Coluccelli
Giulia Dondi
Marco Tesei
Pierandrea De Iaco
Paolo Castellucci
Giuseppe Gasparre
Anna Myriam Perrone
Cristina Nanni
Anna Maria Porcelli
Giacomo Maria Lima
Perrone, Anna Myriam
Dondi, Giulia
Lima, Giacomo Maria
Castellucci, Paolo
Tesei, Marco
Coluccelli, Sara
Gasparre, Giuseppe
Porcelli, Anna Maria
Nanni, Cristina
Fanti, Stefano
De Iaco, Pierandrea
Source :
Cancers, Vol 11, Iss 5, p 713 (2019), Cancers, Volume 11, Issue 5
Publication Year :
2019
Publisher :
MDPI AG, 2019.

Abstract

Epithelial ovarian cancer (EOC) is the most lethal gynecological malignancy, with relapse occurring in about 70% of advanced cases with poor prognosis. Fluorine-18-2-fluoro-2-deoxy-d-glucose PET/CT (18F-FDGPET/CT) is the most specific radiological imaging used to assess recurrence. Some intensity-based and volume-based PET parameters, maximum standardized uptake values (SUVmax), metabolic tumor volume (MTV) and total lesion glycolysis (TLG), are indicated to have a correlation with treatment response. The aim of our study is to correlate these parameters with post relapse survival (PRS) and overall survival (OS) in Epithelial Ovarian Cancer (EOC) relapse. The study included 50 patients affected by EOC relapse who underwent 18F-FDGPET/CT before surgery. All imaging was reviewed and SUVmax, MTV and TLG were calculated and correlated to PRS and OS. PRS and OS were obtained from the first relapse and from the first diagnosis to the last follow up or death, respectively. SUVmax, MTV and TLG were tested in a univariate logistic regression analysis, only SUVmax demonstrated to be significantly associated to PRS and OS (p = 0.005 and p = 0.024 respectively). Multivariate analysis confirmed the results. We found a cut-off of SUVmax of 13 that defined worse or better survival (p = 0.003). In the first relapse of EOC, SUVmax is correlated to PRS and OS, and when SUVmax is greater than 13, it is an unfavorable prognostic factor.

Details

Language :
English
ISSN :
20726694
Volume :
11
Issue :
5
Database :
OpenAIRE
Journal :
Cancers
Accession number :
edsair.doi.dedup.....c7ced523180fd137037918e487fcfded