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Oxidative bioelectrocatalysis: From natural metabolic pathways to synthetic metabolons and minimal enzyme cascades
- Source :
- Biochimica et biophysica acta. 1857(5)
- Publication Year :
- 2015
-
Abstract
- Anodic bioelectrodes for biofuel cells are more complex than cathodic bioelectrodes for biofuel cells, because laccase and bilirubin oxidase can individually catalyze four electron reduction of oxygen to water, whereas most anodic enzymes only do a single two electron oxidation of a complex fuel (i.e. glucose oxidase oxidizing glucose to gluconolactone while generating 2 electrons of the total 24 electrons), so enzyme cascades are typically needed for complete oxidation of the fuel. This review article will discuss the lessons learned from natural metabolic pathways about multi-step oxidation and how those lessons have been applied to minimal or artificial enzyme cascades. This article is part of a Special Issue entitled Biodesign for Bioenergetics--the design and engineering of electronic transfer cofactors, proteins and protein networks, edited by Ronald L. Koder and J.L. Ross Anderson.
- Subjects :
- Biophysics
02 engineering and technology
Oxidative phosphorylation
010402 general chemistry
Protein Engineering
01 natural sciences
Biochemistry
Gluconolactone
Electron Transport
Animals
Humans
Metabolomics
Glucose oxidase
Bilirubin oxidase
biology
Chemistry
Artificial enzyme
Cell Biology
021001 nanoscience & nanotechnology
Electron transport chain
0104 chemical sciences
Enzymes
Metabolic pathway
biology.protein
Biocatalysis
Synthetic Biology
Metabolon
0210 nano-technology
Oxidation-Reduction
Metabolic Networks and Pathways
Subjects
Details
- ISSN :
- 00063002
- Volume :
- 1857
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Biochimica et biophysica acta
- Accession number :
- edsair.doi.dedup.....c7ccf752ada708705a3235bde986f64f