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A single-cell transcriptome atlas of the aging human and macaque retina
- Source :
- National Science Review
- Publication Year :
- 2020
- Publisher :
- Oxford University Press, 2020.
-
Abstract
- The human retina is a complex neural tissue that detects light and sends visual information to the brain. However, the molecular and cellular processes that underlie aging primate retina remain unclear. Here, we provide a comprehensive transcriptomic atlas based on 119,520 single cells of the foveal and peripheral retina of humans and macaques covering different ages. The molecular features of retinal cells differed between the two species, suggesting the distinct regional and species specializations of the human and macaque retinae. In addition, human retinal aging occurred in a region- and cell-type- specific manner. Aging of human retina exhibited a foveal to peripheral gradient. MYO9A− rods and a horizontal cell subtype were greatly reduced in aging retina, indicating their vulnerability to aging. Moreover, we generated a dataset showing the cell-type- and region- specific gene expression associated with 55 types of human retinal disease, which provides a foundation to understand the molecular and cellular mechanisms underlying human retinal diseases. Together, these datasets are valuable for understanding the molecular characteristics of primate retina, as well as the molecular regulation of aging progression and related diseases.
- Subjects :
- genetic structures
AcademicSubjects/SCI00010
cell heterogeneity
Cell
02 engineering and technology
010402 general chemistry
01 natural sciences
Macaque
single-cell RNA sequencing
Transcriptome
chemistry.chemical_compound
Foveal
biology.animal
Gene expression
medicine
Primate
cell-cell communication
Retina
age-related disease
Multidisciplinary
biology
Molecular Biology & Genetics
aging
Retinal
primate retina
021001 nanoscience & nanotechnology
eye diseases
0104 chemical sciences
medicine.anatomical_structure
chemistry
sense organs
0210 nano-technology
AcademicSubjects/MED00010
Neuroscience
Research Article
Subjects
Details
- Language :
- English
- ISSN :
- 2053714X and 20955138
- Volume :
- 8
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- National Science Review
- Accession number :
- edsair.doi.dedup.....c7c1f16cfac857b433791f6b5be69821