Back to Search
Start Over
Design and synthesis of potent pyridazine inhibitors of p38 MAP kinase
- Source :
- Bioorganicmedicinal chemistry letters. 15(9)
- Publication Year :
- 2005
-
Abstract
- Novel potent trisubstituted pyridazine inhibitors of p38 MAP (mitogen activated protein) kinase are described that have activity in both cell-based assays of cytokine release and animal models of rheumatoid arthritis. They demonstrated potent inhibition of LPS-induced TNF-alpha production in mice and exhibited good efficacy in the rat collagen induced arthritis model.
- Subjects :
- Models, Molecular
Protein Conformation
p38 mitogen-activated protein kinases
medicine.medical_treatment
Clinical Biochemistry
Pharmaceutical Science
Arthritis
Biochemistry
p38 Mitogen-Activated Protein Kinases
Structure-Activity Relationship
Drug Discovery
medicine
Humans
Enzyme Inhibitors
Protein kinase A
Molecular Biology
Binding Sites
biology
Molecular Structure
Chemistry
Kinase
Organic Chemistry
medicine.disease
Pyridazines
Kinetics
Cytokine
Enzyme inhibitor
Mitogen-activated protein kinase
Drug Design
biology.protein
Microsomes, Liver
Molecular Medicine
Indicators and Reagents
Signal transduction
Subjects
Details
- ISSN :
- 0960894X
- Volume :
- 15
- Issue :
- 9
- Database :
- OpenAIRE
- Journal :
- Bioorganicmedicinal chemistry letters
- Accession number :
- edsair.doi.dedup.....c7beff53dd4a69f2db09421329f14f61