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Three cases of acute-onset bilateral photophobia
- Source :
- Japanese Journal of Ophthalmology. 63:172-180
- Publication Year :
- 2019
- Publisher :
- Springer Science and Business Media LLC, 2019.
-
Abstract
- To report the findings in 3 cases of bilateral negative electroretinograms (ERGs) with acute onset of photophobia. Retrospective case series. The medical charts of the 3 patients were reviewed. A 43-year-old woman, a 68-year-old woman, and a 41-year-old woman were referred to Nagoya University Hospital. Their main symptom was bilateral acute photophobia. None of the patients had any systemic diseases or specific medical history. The decimal best-corrected visual acuity (> 0.8) and Humphrey visual fields (mean deviation > -3 dB) were relatively well preserved in all 3 patients. The optical coherence tomography (OCT) and fundus autofluorescence findings were essentially normal. Fluorescein angiography showed mild leakage in 1 patient but no abnormality in the other 2 patients. However, the ERGs of the 3 patients had the features of abnormal ERGs found in patients with incomplete congenital stationary night blindness (CSNB). Exome analyses found no pathogenic variants related to known CSNB-related genes. The symptoms and ERGs of the 3 patients have not progressed or recovered after a relatively long follow-up period. The ERG characteristics of 3 patients with bilateral photophobia were similar to those of incomplete CSNB, suggesting post-phototransductional abnormalities. The symptoms and genetic analyses indicated the possibility of an acquired condition rather than a hereditary retinal disease.
- Subjects :
- Adult
medicine.medical_specialty
Visual acuity
genetic structures
Photophobia
Fundus Oculi
Visual Acuity
Disease
Diagnosis, Differential
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Night Blindness
Ophthalmology
Electroretinography
Myopia
Humans
Medicine
Medical history
Fluorescein Angiography
Aged
Retrospective Studies
medicine.diagnostic_test
business.industry
Eye Diseases, Hereditary
Genetic Diseases, X-Linked
Retinal
General Medicine
Fluorescein angiography
eye diseases
chemistry
Acute Disease
030221 ophthalmology & optometry
Female
sense organs
Abnormality
medicine.symptom
business
Erg
Tomography, Optical Coherence
030217 neurology & neurosurgery
Follow-Up Studies
Subjects
Details
- ISSN :
- 16132246 and 00215155
- Volume :
- 63
- Database :
- OpenAIRE
- Journal :
- Japanese Journal of Ophthalmology
- Accession number :
- edsair.doi.dedup.....c7aadc4970045d3c69d597aea2904692