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A role of themicrophthalmia-associated transcription factorin congenital sensorineural deafness and eye pigmentation in Dalmatian dogs
- Source :
- Journal of Animal Breeding and Genetics. 126:59-62
- Publication Year :
- 2009
- Publisher :
- Wiley, 2009.
-
Abstract
- Microphthalmia-associated transcription factor (MITF) is involved in white spotting and deafness associated with lack of pigmentation in human and mice. In the present study, we employed MITF-associated markers to evaluate MITF as a candidate for canine congenital sensorineural deafness (CCSD) in Dalmatian dogs. We performed an association study using MITF flanking and intragenic markers for 88 Dalmatian dogs of different hearing and eye pigmentation status. A significant association was identified for MITF-related markers with CCSD and blue iris colour. We conclude that MITF might play a role in CCSD and blue eye colour in Dalmatian dogs.
- Subjects :
- Genetic Markers
Linkage disequilibrium
Pathology
medicine.medical_specialty
Genotype
Hearing loss
Hearing Loss, Sensorineural
Biology
Linkage Disequilibrium
Dalmatian dog
Dogs
Food Animals
medicine
Animals
Dog Diseases
DNA Primers
Genetics
Microphthalmia-Associated Transcription Factor
Eye Color
integumentary system
General Medicine
Microphthalmia-associated transcription factor
Eye pigmentation
Iris colour
body regions
Congenital sensorineural deafness
Animal Science and Zoology
sense organs
medicine.symptom
Microsatellite Repeats
Subjects
Details
- ISSN :
- 14390388 and 09312668
- Volume :
- 126
- Database :
- OpenAIRE
- Journal :
- Journal of Animal Breeding and Genetics
- Accession number :
- edsair.doi.dedup.....c7a13568c14369c8b040560e569f3ce3