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Interactions of a paracyclophane-based conjugated oligoelectrolyte with biological membranes
- Source :
- RSC advances. 8(70)
- Publication Year :
- 2018
-
Abstract
- A three-dimensional conjugated oligoelectrolyte (COE) bearing a [2.2]paracyclophane unit (COE2-3-pCp) was synthesized. Its biological activity was determined both in vivo and in silicon within the context of membrane perturbation and biocompatibility. Molecular dynamics simulations indicate that, compared to its linear analog (COE2-3C), COE2-3-pCp introduces more lipid disorder with higher extent of membrane thinning. COE2-3-pCp also exhibits a higher MIC towards E. coli K12 and yeast, while maintaining similar levels of membrane permeabilization. These findings suggest a new design of COEs as biocompatible cell permeabilizers. NRF (Natl Research Foundation, S’pore) MOE (Min. of Education, S’pore) Published version
- Subjects :
- Bioengineering [Engineering]
Biocompatibility
Chemistry
General Chemical Engineering
In silico
Biological membrane
Biological activity
02 engineering and technology
General Chemistry
Conjugated system
010402 general chemistry
021001 nanoscience & nanotechnology
01 natural sciences
Conjugated Oligoelectrolyte
Biological Membranes
0104 chemical sciences
Molecular dynamics
Membrane
In vivo
Biophysics
0210 nano-technology
Subjects
Details
- ISSN :
- 20462069
- Volume :
- 8
- Issue :
- 70
- Database :
- OpenAIRE
- Journal :
- RSC advances
- Accession number :
- edsair.doi.dedup.....c7a1011fe47e93ab80eddec71f9baedb