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Ancient human parvovirus B19 in Eurasia reveals its long-term association with humans
- Source :
- Proceedings of the National Academy of Sciences of the U.S.A., 115(29), 7557-7562. National Academy of Sciences, Proceedings of the National Academy of Sciences
- Publication Year :
- 2018
- Publisher :
- Uppsala universitet, Arkeologi, 2018.
-
Abstract
- Human parvovirus B19 (B19V) is a ubiquitous human pathogen associated with a number of conditions, such as fifth disease in children and arthritis and arthralgias in adults. B19V is thought to evolve exceptionally rapidly among DNA viruses, with substitution rates previously estimated to be closer to those typical of RNA viruses. On the basis of genetic sequences up to similar to 70 years of age, the most recent common ancestor of all B19V has been dated to the early 1800s, and it has been suggested that genotype 1, the most common B19V genotype, only started circulating in the 1960s. Here we present 10 genomes (63.9-99.7% genome coverage) of B19V from dental and skeletal remains of individuals who lived in Eurasia and Greenland from similar to 0.5 to similar to 6.9 thousand years ago (kya). In a phylogenetic analysis, five of the ancient B19V sequences fall within or basal to the modern genotype 1, and five fall basal to genotype 2, showing a long-term association of B19V with humans. The most recent common ancestor of all B19V is placed similar to 12.6 kya, and we find a substitution rate that is an order of magnitude lower than inferred previously. Further, we are able to date the recombination event between genotypes 1 and 3 that formed genotype 2 to similar to 5.0-6.8 kya. This study emphasizes the importance of ancient viral sequences for our understanding of virus evolution and phylogenetics.
- Subjects :
- 0301 basic medicine
Most recent common ancestor
Genotype
viruses
030106 microbiology
Erythema Infectiosum
Genome, Viral
Biology
paleo virology
Genome
Evolution, Molecular
03 medical and health sciences
Basal (phylogenetics)
Phylogenetics
Parvovirus B19, Human
Humans
ancient DNA
Phylogeny
Medicinsk genetik
virus evolution
Multidisciplinary
Phylogenetic tree
parvovirus B19
History, 19th Century
Sequence Analysis, DNA
History, 20th Century
Biological Sciences
3. Good health
virology
030104 developmental biology
Ancient DNA
Evolutionary biology
Viral evolution
Medical Genetics
Subjects
Details
- Language :
- English
- ISSN :
- 00278424
- Database :
- OpenAIRE
- Journal :
- Proceedings of the National Academy of Sciences of the U.S.A., 115(29), 7557-7562. National Academy of Sciences, Proceedings of the National Academy of Sciences
- Accession number :
- edsair.doi.dedup.....c79e9516b7801dc93ec47c6e24ce645a