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Exchange transfusion activates coagulation and alters the coagulation profile in newborn infants
- Source :
- Thrombosis and Haemostasis. 96:142-148
- Publication Year :
- 2006
- Publisher :
- Georg Thieme Verlag KG, 2006.
-
Abstract
- SummaryExchange transfusion (ET) with adult blood is a standard procedure for neonates with severe hyperbilirubinemia. How ET affects newborn coagulation system remains, however, largely unknown. Thus, we prospectively evaluated the effect of ET on thrombin formation and coagulation profile in 18 newborns (22 ETs). Prothrombin fragment F1+2 and thrombin-antithrombin complexes increased considerably during ET while platelets were significantly reduced. Protein C increased less (p90% of adult levels. ETP and peak remained elevated at adult levels until the beginning of the second ET. APC-induced reductions in newborn ETP remained unaltered throughout the first ET. The reductions of ETP by APC were less pronounced in newborn than adult plasma (p
- Subjects :
- Adult
medicine.medical_specialty
Time Factors
medicine.medical_treatment
Exchange transfusion
Biology
Standard procedure
Thrombin
Coagulation profile
Internal medicine
medicine
Humans
Blood Transfusion
Platelet
Prothrombin fragment
Blood Coagulation
Coagulants
Infant, Newborn
Anticoagulants
Hematology
Endocrinology
Coagulation
Immunology
Female
Blood Coagulation Tests
Protein C
medicine.drug
Subjects
Details
- ISSN :
- 2567689X and 03406245
- Volume :
- 96
- Database :
- OpenAIRE
- Journal :
- Thrombosis and Haemostasis
- Accession number :
- edsair.doi.dedup.....c78adf1d9b64bc0c5fa76aa12b27502b